Component
Human CAMP gene
Study-defined Human CAMP gene. Read each linked record for species, exposure and endpoint.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Calcitriol induced CAMP expression in tested human myeloid, keratinocyte and colon cell models and bone-marrow-derived cells.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- Human cell lines and bone-marrow-derived cells; promoter studies and mouse comparison
- exposure
- Calcitriol-treated primary cells and cell lines; concentrations not recovered from the abstract.
- limitations
- Human cell and promoter experiments; no oral D2/D3 efficacy or infection-incidence trial.
- nutrient_topic
- Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin D2 and D3
- organism
- Homo sapiens
- plain_language
- The active D3 hormone increased the instructions for an antimicrobial protein.
- primary_references
- [gombart2005] Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. (2005). https://pubmed.ncbi.nlm.nih.gov/15985530/ DOI: 10.1096/fj.04-3284com
- tissue_or_cell_type
- Human myeloid and epithelial cells
Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 905–916
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human cell lines and bone-marrow-derived cells; promoter studies and mouse comparison · source_derived_draft · unverified_draft
### vd-camp-transcription Calcitriol induced CAMP expression in tested human myeloid, keratinocyte and colon cell models and bone-marrow-derived cells. Condition category: normal nutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The active D3 hormone increased the instructions for an antimicrobial protein. organism: Homo sapiens tissue_or_cell_type: Human myeloid and epithelial cells experimental_model: Human cell lines and bone-marrow-derived cells; promoter studies and mouse comparison limitations: Human cell and promoter experiments; no oral D2/D3 efficacy or infection-incidence trial. exposure: Calcitriol-treated primary cells and cell lines; concentrations not recovered from the abstract. cross_nutrient: false [gombart2005] Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. (2005). https://pubmed.ncbi.nlm.nih.gov/15985530/ DOI: 10.1096/fj.04-3284com
Complete structured claim and evidenceVDR bound a consensus vitamin D response element in the human CAMP promoter; this element mediated the observed induction.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- Human cell lines and bone-marrow-derived cells; promoter studies and mouse comparison
- exposure
- Promoter binding and functional response-element experiments.
- limitations
- Human cell and promoter experiments; no oral D2/D3 efficacy or infection-incidence trial.
- nutrient_topic
- Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin D2 and D3
- organism
- Homo sapiens
- plain_language
- The receptor connects the active hormone to a specific DNA control element.
- primary_references
- [gombart2005] Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. (2005). https://pubmed.ncbi.nlm.nih.gov/15985530/ DOI: 10.1096/fj.04-3284com
- tissue_or_cell_type
- Human CAMP promoter
Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 918–929
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human cell lines and bone-marrow-derived cells; promoter studies and mouse comparison · source_derived_draft · unverified_draft
### vd-camp-vdre VDR bound a consensus vitamin D response element in the human CAMP promoter; this element mediated the observed induction. Condition category: normal nutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The receptor connects the active hormone to a specific DNA control element. organism: Homo sapiens tissue_or_cell_type: Human CAMP promoter experimental_model: Human cell lines and bone-marrow-derived cells; promoter studies and mouse comparison limitations: Human cell and promoter experiments; no oral D2/D3 efficacy or infection-incidence trial. exposure: Promoter binding and functional response-element experiments. cross_nutrient: false [gombart2005] Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. (2005). https://pubmed.ncbi.nlm.nih.gov/15985530/ DOI: 10.1096/fj.04-3284com
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.