{"id":"cd91c00b-de70-593e-a97d-2f144c47de75","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-camp-vdre","predicate":"binds","statement":"VDR bound a consensus vitamin D response element in the human CAMP promoter; this element mediated the observed induction.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"cf62119b-b1c9-56c9-9b17-00e3bfa81268","mechanism_event_label":"The receptor connects the active hormone to a specific DNA control element.","subject":{"id":"d725020b-bacc-5e90-b370-cda246025c91","slug":"vdr","display_name":"Vitamin D receptor / VDR","entity_type_key":"protein"},"object":{"id":"71372604-7e75-51c8-bcfa-be0ed21014ac","slug":"human-camp-promoter-vdre","display_name":"Human CAMP promoter vitamin D response element","entity_type_key":"gene"},"evidence_count":1,"mechanism_event":{"id":"cf62119b-b1c9-56c9-9b17-00e3bfa81268","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-camp-vdre-event","event_type":"biochemical_relationship","label":"The receptor connects the active hormone to a specific DNA control element.","description":"VDR bound a consensus vitamin D response element in the human CAMP promoter; this element mediated the observed induction.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f5156c24-108f-5746-b114-ed764e79a3f4","slug":"calcitriol","display_name":"Calcitriol","entity_type_key":"small_molecule"},"role":"ligand","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"dd90d944-35f9-534e-b148-697757e8660d","slug":"human-camp-gene","display_name":"Human CAMP gene","entity_type_key":"gene"},"role":"regulated-gene","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"d725020b-bacc-5e90-b370-cda246025c91","slug":"vdr","display_name":"Vitamin D receptor / VDR","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"71372604-7e75-51c8-bcfa-be0ed21014ac","slug":"human-camp-promoter-vdre","display_name":"Human CAMP promoter vitamin D response element","entity_type_key":"gene"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human cell lines and bone-marrow-derived cells; promoter studies and mouse comparison","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Promoter binding and functional response-element experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Human cell and promoter experiments; no oral D2/D3 efficacy or infection-incidence trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-d","display_name":"Vitamin D2 and D3","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The receptor connects the active hormone to a specific DNA control element.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[gombart2005] Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. (2005). https://pubmed.ncbi.nlm.nih.gov/15985530/ DOI: 10.1096/fj.04-3284com","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human CAMP promoter","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"44da1efc-e510-527c-8c09-7e95343ce001","evidence_kind":"source_excerpt","locator":"Lines 918-929","start_line":918,"end_line":929,"excerpt":"### vd-camp-vdre\nVDR bound a consensus vitamin D response element in the human CAMP promoter; this element mediated the observed induction.\nCondition category: normal\nnutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The receptor connects the active hormone to a specific DNA control element.\norganism: Homo sapiens\ntissue_or_cell_type: Human CAMP promoter\nexperimental_model: Human cell lines and bone-marrow-derived cells; promoter studies and mouse comparison\nlimitations: Human cell and promoter experiments; no oral D2/D3 efficacy or infection-incidence trial.\nexposure: Promoter binding and functional response-element experiments.\ncross_nutrient: false\n[gombart2005] Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. (2005). https://pubmed.ncbi.nlm.nih.gov/15985530/ DOI: 10.1096/fj.04-3284com","model_system":"Human cell lines and bone-marrow-derived cells; promoter studies and mouse comparison","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [gombart2005] Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. 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