Component

C3G transport across differentiated human Caco-2 monolayers

C3G transport across differentiated human Caco-2 monolayers. Interpret through the linked experimental species, preparation, compartment and exposure; no universal causal effect is implied.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Knocking down SLC2A2 reduced C3G transport in differentiated human Caco-2 monolayers relative to scrambled siRNA.

    Cyanidin 3-O-beta-D-glucopyranoside → C3G transport across differentiated human Caco-2 monolayers source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Full text retrieved; relevant methods/results/figure text reviewed. No independent raw-data verification.
    experimental_condition
    C3G exposure with scrambled siRNA siRNA knockdown · Human glucose transporter 2 / SLC2A2 / GLUT2 Condition belongs to the full experimental contrast; do not separate a joint intervention.
    experimental_condition
    C3G exposure with scrambled siRNA present · Cyanidin 3-O-beta-D-glucopyranoside Condition belongs to the full experimental contrast; do not separate a joint intervention.
    experimental_contrast
    {"intervention": "C3G exposure with SLC2A2 siRNA", "comparator": "C3G exposure with scrambled siRNA", "endpoint": "Knocking down SLC2A2 reduced C3G transport in differentiated human Caco-2 monolayers relative to scrambled siRNA.", "effect_direction": "decrease", "combination": "joint", "conditions": [{"entity_slug": "slc2a2", "state": "siRNA knockdown"}, {"entity_slug": "cyanidin-3-glucoside", "state": "present"}]} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    Differentiated human Caco-2; 10-40 uM C3G transport experiments up to 120 min; siRNA comparison.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Knockdown result, not a wild-type inhibitory action of the transporter. Does not quantify its contribution to human in vivo absorption.
    plain_language
    Knocking down SLC2A2 reduced C3G transport in differentiated human Caco-2 monolayers relative to scrambled siRNA.
    primary_references
    The role of sodium-dependent glucose transporter 1 and glucose transporter 2 in the absorption of cyanidin-3-o-β-glucoside in Caco-2 cells. | 2014 | DOI 10.3390/nu6104165 | PMID 25314643 | https://pubmed.ncbi.nlm.nih.gov/25314643/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC4210911/ | https://doi.org/10.3390/nu6104165
    source_locator
    Reviewed reference lines 38-38; exact primary location described in quoted passage where extracted.
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Anthocyanins: detailed mechanisms of action (reviewed 4 October 2026) · lines 38–38

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Differentiated human Caco-2; 10-40 uM C3G transport experiments up to 120 min; siRNA comparison. · source_derived_draft · unverified_draft

    **SGLT1 and GLUT2 have experimental support.** In differentiated human Caco-2 monolayers, pharmacological inhibition and separate SGLT1 or GLUT2 siRNA reduced C3G transport. Transport was examined across 10–40 µM C3G and up to 120 minutes; scrambled siRNA provided a comparator. This supports involvement in that epithelial model, not an exclusive absorption route or a measured contribution in the human intestine. Canonical proteins are SLC5A1/SGLT1 and SLC2A2/GLUT2. [Zou et al., 2014](https://pmc.ncbi.nlm.nih.gov/articles/PMC4210911/).
    Complete structured claim and evidence

  2. Knocking down SLC5A1 reduced C3G transport in differentiated human Caco-2 monolayers relative to scrambled siRNA.

    Cyanidin 3-O-beta-D-glucopyranoside → C3G transport across differentiated human Caco-2 monolayers source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Full text retrieved; relevant methods/results/figure text reviewed. No independent raw-data verification.
    experimental_condition
    C3G exposure with scrambled siRNA present · Cyanidin 3-O-beta-D-glucopyranoside Condition belongs to the full experimental contrast; do not separate a joint intervention.
    experimental_condition
    C3G exposure with scrambled siRNA siRNA knockdown · Human sodium/glucose cotransporter SGLT1 / SLC5A1 Condition belongs to the full experimental contrast; do not separate a joint intervention.
    experimental_contrast
    {"intervention": "C3G exposure with SLC5A1 siRNA", "comparator": "C3G exposure with scrambled siRNA", "endpoint": "Knocking down SLC5A1 reduced C3G transport in differentiated human Caco-2 monolayers relative to scrambled siRNA.", "effect_direction": "decrease", "combination": "joint", "conditions": [{"entity_slug": "slc5a1", "state": "siRNA knockdown"}, {"entity_slug": "cyanidin-3-glucoside", "state": "present"}]} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    Differentiated human Caco-2; 10-40 uM C3G transport experiments up to 120 min; siRNA comparison.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Knockdown result, not a wild-type inhibitory action of the transporter. Does not quantify its contribution to human in vivo absorption.
    plain_language
    Knocking down SLC5A1 reduced C3G transport in differentiated human Caco-2 monolayers relative to scrambled siRNA.
    primary_references
    The role of sodium-dependent glucose transporter 1 and glucose transporter 2 in the absorption of cyanidin-3-o-β-glucoside in Caco-2 cells. | 2014 | DOI 10.3390/nu6104165 | PMID 25314643 | https://pubmed.ncbi.nlm.nih.gov/25314643/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC4210911/ | https://doi.org/10.3390/nu6104165
    source_locator
    Reviewed reference lines 38-38; exact primary location described in quoted passage where extracted.
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Anthocyanins: detailed mechanisms of action (reviewed 4 October 2026) · lines 38–38

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Differentiated human Caco-2; 10-40 uM C3G transport experiments up to 120 min; siRNA comparison. · source_derived_draft · unverified_draft

    **SGLT1 and GLUT2 have experimental support.** In differentiated human Caco-2 monolayers, pharmacological inhibition and separate SGLT1 or GLUT2 siRNA reduced C3G transport. Transport was examined across 10–40 µM C3G and up to 120 minutes; scrambled siRNA provided a comparator. This supports involvement in that epithelial model, not an exclusive absorption route or a measured contribution in the human intestine. Canonical proteins are SLC5A1/SGLT1 and SLC2A2/GLUT2. [Zou et al., 2014](https://pmc.ncbi.nlm.nih.gov/articles/PMC4210911/).
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.