Component

2-NBDG uptake by human Caco-2 BBe1 cells

2-NBDG uptake by human Caco-2 BBe1 cells. Interpret through the linked experimental species, preparation, compartment and exposure; no universal causal effect is implied.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. The tested cyanidin glycoside reduced fluorescent glucose-analogue uptake in Caco-2 BBe1 cells at 50 uM.

    Cyanidin 3,5-O-diglucoside / cyanin → 2-NBDG uptake by human Caco-2 BBe1 cells source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Full text retrieved; relevant methods/results/figure text reviewed. No independent raw-data verification.
    experimental_contrast
    {"intervention": "50 uM cyanidin-3-5-diglucoside", "comparator": "Cell assay without added glycoside", "endpoint": "The tested cyanidin glycoside reduced fluorescent glucose-analogue uptake in Caco-2 BBe1 cells at 50 uM.", "effect_direction": "decrease", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    Human Caco-2 BBe1; 50 uM flavonoid pretreatment, fluorescent 2-NBDG uptake; not dietary human glucose absorption.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Fluorescent analogue outcome, not verified clinical glycemic benefit or carbohydrate deficiency.
    plain_language
    The tested cyanidin glycoside reduced fluorescent glucose-analogue uptake in Caco-2 BBe1 cells at 50 uM.
    primary_references
    Molecular Mechanisms Underlying the Absorption of Aglycone and Glycosidic Flavonoids in a Caco-2 BBe1 Cell Model. | 2020 | DOI 10.1021/acsomega.0c00379 | PMID 32455198 | https://pubmed.ncbi.nlm.nih.gov/32455198/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC7240828/ | https://doi.org/10.1021/acsomega.0c00379
    source_locator
    Reviewed reference lines 40-40; exact primary location described in quoted passage where extracted.

    Anthocyanins: detailed mechanisms of action (reviewed 4 October 2026) · lines 40–40

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Human Caco-2 BBe1; 50 uM flavonoid pretreatment, fluorescent 2-NBDG uptake; not dietary human glucose absorption. · source_derived_draft · unverified_draft

    **Glucose handling is a separate cross-nutrient interaction.** A Caco-2 BBe1 study tested cyanidin and glycosides alongside quercetin compounds. At 50 µM, the glycosides reduced uptake of the fluorescent glucose analogue 2-NBDG. Transport inhibition and SGLT1 knockdown supported carrier involvement in glycoside uptake, with different behavior for aglycones. This is a nutrient-transport interaction in cultured cells; it is not proof that ordinary berry intake blocks intestinal glucose absorption or causes carbohydrate deficiency. [Zhang et al., 2020, transport and glucose-uptake experiments](https://pmc.ncbi.nlm.nih.gov/articles/PMC7240828/).
    Complete structured claim and evidence

  2. The tested cyanidin glycoside reduced fluorescent glucose-analogue uptake in Caco-2 BBe1 cells at 50 uM.

    Cyanidin 3-O-beta-D-glucopyranoside → 2-NBDG uptake by human Caco-2 BBe1 cells source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Full text retrieved; relevant methods/results/figure text reviewed. No independent raw-data verification.
    experimental_contrast
    {"intervention": "50 uM cyanidin-3-glucoside", "comparator": "Cell assay without added glycoside", "endpoint": "The tested cyanidin glycoside reduced fluorescent glucose-analogue uptake in Caco-2 BBe1 cells at 50 uM.", "effect_direction": "decrease", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    Human Caco-2 BBe1; 50 uM flavonoid pretreatment, fluorescent 2-NBDG uptake; not dietary human glucose absorption.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Fluorescent analogue outcome, not verified clinical glycemic benefit or carbohydrate deficiency.
    plain_language
    The tested cyanidin glycoside reduced fluorescent glucose-analogue uptake in Caco-2 BBe1 cells at 50 uM.
    primary_references
    Molecular Mechanisms Underlying the Absorption of Aglycone and Glycosidic Flavonoids in a Caco-2 BBe1 Cell Model. | 2020 | DOI 10.1021/acsomega.0c00379 | PMID 32455198 | https://pubmed.ncbi.nlm.nih.gov/32455198/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC7240828/ | https://doi.org/10.1021/acsomega.0c00379
    source_locator
    Reviewed reference lines 40-40; exact primary location described in quoted passage where extracted.

    Anthocyanins: detailed mechanisms of action (reviewed 4 October 2026) · lines 40–40

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Human Caco-2 BBe1; 50 uM flavonoid pretreatment, fluorescent 2-NBDG uptake; not dietary human glucose absorption. · source_derived_draft · unverified_draft

    **Glucose handling is a separate cross-nutrient interaction.** A Caco-2 BBe1 study tested cyanidin and glycosides alongside quercetin compounds. At 50 µM, the glycosides reduced uptake of the fluorescent glucose analogue 2-NBDG. Transport inhibition and SGLT1 knockdown supported carrier involvement in glycoside uptake, with different behavior for aglycones. This is a nutrient-transport interaction in cultured cells; it is not proof that ordinary berry intake blocks intestinal glucose absorption or causes carbohydrate deficiency. [Zhang et al., 2020, transport and glucose-uptake experiments](https://pmc.ncbi.nlm.nih.gov/articles/PMC7240828/).
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.