Component
Human blood pressure after butyrate administration
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
In 23 hypertensive adults, 3.9 g/day oral sodium butyrate for four weeks increased daytime systolic pressure by 9.63 mmHg and diastolic pressure by 5.08 mmHg versus sodium-matched placebo.
Experimental context and source evidence
- evidence_access
- Primary full text, intervention methods and primary results
- experimental_model
- Double-blind randomized trial after supervised antihypertensive washout; sodium chloride placebo matched the sodium load.
- limitations
- Small short trial; do not infer the increase was simply unmatched sodium or advise medication changes.
- nutrient_topic
- Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Butyrate
- plain_language
- An oral human trial found higher blood pressure.
- primary_references
- Effects of Oral Butyrate on Blood Pressure in Patients With Hypertension: A Randomized, Placebo-Controlled Trial. · 2024 · https://pubmed.ncbi.nlm.nih.gov/39034917/ · DOI 10.1161/HYPERTENSIONAHA.123.22437
Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19) · lines 582–588
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Double-blind randomized trial after supervised antihypertensive washout; sodium chloride placebo matched the sodium load. · source_derived_draft · unverified_draft
## butyrate-oral-bp-increase An oral human trial found higher blood pressure. In 23 hypertensive adults, 3.9 g/day oral sodium butyrate for four weeks increased daytime systolic pressure by 9.63 mmHg and diastolic pressure by 5.08 mmHg versus sodium-matched placebo. Model: Double-blind randomized trial after supervised antihypertensive washout; sodium chloride placebo matched the sodium load. Limitations: Small short trial; do not infer the increase was simply unmatched sodium or advise medication changes. Evidence access: Primary full text, intervention methods and primary results Effects of Oral Butyrate on Blood Pressure in Patients With Hypertension: A Randomized, Placebo-Controlled Trial. · 2024 · https://pubmed.ncbi.nlm.nih.gov/39034917/ · DOI 10.1161/HYPERTENSIONAHA.123.22437
Complete structured claim and evidenceTen Black adults with stage-1 hypertension had lower daytime systolic pressure after an acute 80 mM butyrate enema in a crossover comparison with a 5 mM low-dose enema.
Experimental context and source evidence
- evidence_access
- Primary full text, dose/control design and results
- experimental_model
- Randomized crossover, seven-day separation; 24-hour ambulatory monitoring.
- limitations
- The comparator contained butyrate, not inert placebo; acute rectal delivery is not four-week oral treatment.
- nutrient_topic
- Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Butyrate
- plain_language
- A small study using a different delivery route found a lower-pressure response.
- primary_references
- Effect of Acute Gut Butyrate Delivery on Blood Pressure in Black Individuals With Hypertension: A Proof-of-Concept Randomized Controlled Study. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40736085/ · DOI 10.1161/JAHA.124.039759
Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19) · lines 590–596
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Randomized crossover, seven-day separation; 24-hour ambulatory monitoring. · source_derived_draft · unverified_draft
## butyrate-rectal-bp-decrease A small study using a different delivery route found a lower-pressure response. Ten Black adults with stage-1 hypertension had lower daytime systolic pressure after an acute 80 mM butyrate enema in a crossover comparison with a 5 mM low-dose enema. Model: Randomized crossover, seven-day separation; 24-hour ambulatory monitoring. Limitations: The comparator contained butyrate, not inert placebo; acute rectal delivery is not four-week oral treatment. Evidence access: Primary full text, dose/control design and results Effect of Acute Gut Butyrate Delivery on Blood Pressure in Black Individuals With Hypertension: A Proof-of-Concept Randomized Controlled Study. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40736085/ · DOI 10.1161/JAHA.124.039759
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.