Component

Whole-blood interferon alpha response gene-set expression

Study-defined Whole-blood interferon alpha response gene-set expression. Read each linked record for species, exposure and endpoint.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. The interferon-alpha response gene set was negatively enriched at week 12 versus baseline within the white-European D2 group (GSEA adjusted P≤ 0.05).

    Ergocalciferol / vitamin D2 → Whole-blood interferon alpha response gene-set expression source_derived_draftungraded
    Experimental context and source evidence
    analysis_scope
    Within-group baseline-to-week 12 GSEA; not a randomized treatment-versus-placebo contrast.
    cross_nutrient
    false
    experimental_model
    97 participant transcriptomic subset of Tripkovic 2017; 67 white-European and 30 South-Asian women
    exposure
    15 micrograms/day D2 or D3 or placebo for 12 winter weeks; blood microarrays at baseline/end.
    limitations
    Exploratory selected trial subset; differences in baseline status, season and whole-blood cell composition may matter. Within-group significance is not a significant difference between groups; no infection endpoint.
    nutrient_topic
    Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin D2 and D3
    organism
    Homo sapiens
    plain_language
    This was a time trend in a gene set within one study group, not proof of improved infection resistance.
    primary_references
    [durrant2022] Vitamins D2 and D3 Have Overlapping But Different Effects on the Human Immune System Revealed Through Analysis of the Blood Transcriptome. (2022). https://pubmed.ncbi.nlm.nih.gov/35281034/ DOI: 10.3389/fimmu.2022.790444
    tissue_or_cell_type
    Whole blood

    Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1128–1140

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 97 participant transcriptomic subset of Tripkovic 2017; 67 white-European and 30 South-Asian women · source_derived_draft · unverified_draft

    ### vd-durrant-d2-white-european-alpha The interferon-alpha response gene set was negatively enriched at week 12 versus baseline within the white-European D2 group (GSEA adjusted P≤ 0.05). Condition category: normal nutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. plain_language: This was a time trend in a gene set within one study group, not proof of improved infection resistance. organism: Homo sapiens tissue_or_cell_type: Whole blood experimental_model: 97 participant transcriptomic subset of Tripkovic 2017; 67 white-European and 30 South-Asian women limitations: Exploratory selected trial subset; differences in baseline status, season and whole-blood cell composition may matter. Within-group significance is not a significant difference between groups; no infection endpoint. exposure: 15 micrograms/day D2 or D3 or placebo for 12 winter weeks; blood microarrays at baseline/end. cross_nutrient: false analysis_scope: Within-group baseline-to-week 12 GSEA; not a randomized treatment-versus-placebo contrast. [durrant2022] Vitamins D2 and D3 Have Overlapping But Different Effects on the Human Immune System Revealed Through Analysis of the Blood Transcriptome. (2022). https://pubmed.ncbi.nlm.nih.gov/35281034/ DOI: 10.3389/fimmu.2022.790444
    Complete structured claim and evidence

  2. The interferon-alpha response gene set was negatively enriched at week 12 versus baseline within the South-Asian D3 group (GSEA adjusted P≤ 0.05).

    Cholecalciferol → Whole-blood interferon alpha response gene-set expression source_derived_draftungraded
    Experimental context and source evidence
    analysis_scope
    Within-group baseline-to-week 12 GSEA; not a randomized treatment-versus-placebo contrast.
    cross_nutrient
    false
    experimental_model
    97 participant transcriptomic subset of Tripkovic 2017; 67 white-European and 30 South-Asian women
    exposure
    15 micrograms/day D2 or D3 or placebo for 12 winter weeks; blood microarrays at baseline/end.
    limitations
    Exploratory selected trial subset; differences in baseline status, season and whole-blood cell composition may matter. Within-group significance is not a significant difference between groups; no infection endpoint.
    nutrient_topic
    Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin D2 and D3
    organism
    Homo sapiens
    plain_language
    This was a time trend in a gene set within one study group, not proof of improved infection resistance.
    primary_references
    [durrant2022] Vitamins D2 and D3 Have Overlapping But Different Effects on the Human Immune System Revealed Through Analysis of the Blood Transcriptome. (2022). https://pubmed.ncbi.nlm.nih.gov/35281034/ DOI: 10.3389/fimmu.2022.790444
    tissue_or_cell_type
    Whole blood

    Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1156–1168

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 97 participant transcriptomic subset of Tripkovic 2017; 67 white-European and 30 South-Asian women · source_derived_draft · unverified_draft

    ### vd-durrant-d3-south-asian-alpha The interferon-alpha response gene set was negatively enriched at week 12 versus baseline within the South-Asian D3 group (GSEA adjusted P≤ 0.05). Condition category: normal nutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. plain_language: This was a time trend in a gene set within one study group, not proof of improved infection resistance. organism: Homo sapiens tissue_or_cell_type: Whole blood experimental_model: 97 participant transcriptomic subset of Tripkovic 2017; 67 white-European and 30 South-Asian women limitations: Exploratory selected trial subset; differences in baseline status, season and whole-blood cell composition may matter. Within-group significance is not a significant difference between groups; no infection endpoint. exposure: 15 micrograms/day D2 or D3 or placebo for 12 winter weeks; blood microarrays at baseline/end. cross_nutrient: false analysis_scope: Within-group baseline-to-week 12 GSEA; not a randomized treatment-versus-placebo contrast. [durrant2022] Vitamins D2 and D3 Have Overlapping But Different Effects on the Human Immune System Revealed Through Analysis of the Blood Transcriptome. (2022). https://pubmed.ncbi.nlm.nih.gov/35281034/ DOI: 10.3389/fimmu.2022.790444
    Complete structured claim and evidence

  3. The interferon-alpha response gene set was positively enriched at week 12 versus baseline within the white-European D3 group (GSEA adjusted P≤ 0.05).

    Cholecalciferol → Whole-blood interferon alpha response gene-set expression source_derived_draftungraded
    Experimental context and source evidence
    analysis_scope
    Within-group baseline-to-week 12 GSEA; not a randomized treatment-versus-placebo contrast.
    cross_nutrient
    false
    experimental_model
    97 participant transcriptomic subset of Tripkovic 2017; 67 white-European and 30 South-Asian women
    exposure
    15 micrograms/day D2 or D3 or placebo for 12 winter weeks; blood microarrays at baseline/end.
    limitations
    Exploratory selected trial subset; differences in baseline status, season and whole-blood cell composition may matter. Within-group significance is not a significant difference between groups; no infection endpoint.
    nutrient_topic
    Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin D2 and D3
    organism
    Homo sapiens
    plain_language
    This was a time trend in a gene set within one study group, not proof of improved infection resistance.
    primary_references
    [durrant2022] Vitamins D2 and D3 Have Overlapping But Different Effects on the Human Immune System Revealed Through Analysis of the Blood Transcriptome. (2022). https://pubmed.ncbi.nlm.nih.gov/35281034/ DOI: 10.3389/fimmu.2022.790444
    tissue_or_cell_type
    Whole blood

    Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1100–1112

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 97 participant transcriptomic subset of Tripkovic 2017; 67 white-European and 30 South-Asian women · source_derived_draft · unverified_draft

    ### vd-durrant-d3-white-european-alpha The interferon-alpha response gene set was positively enriched at week 12 versus baseline within the white-European D3 group (GSEA adjusted P≤ 0.05). Condition category: normal nutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. plain_language: This was a time trend in a gene set within one study group, not proof of improved infection resistance. organism: Homo sapiens tissue_or_cell_type: Whole blood experimental_model: 97 participant transcriptomic subset of Tripkovic 2017; 67 white-European and 30 South-Asian women limitations: Exploratory selected trial subset; differences in baseline status, season and whole-blood cell composition may matter. Within-group significance is not a significant difference between groups; no infection endpoint. exposure: 15 micrograms/day D2 or D3 or placebo for 12 winter weeks; blood microarrays at baseline/end. cross_nutrient: false analysis_scope: Within-group baseline-to-week 12 GSEA; not a randomized treatment-versus-placebo contrast. [durrant2022] Vitamins D2 and D3 Have Overlapping But Different Effects on the Human Immune System Revealed Through Analysis of the Blood Transcriptome. (2022). https://pubmed.ncbi.nlm.nih.gov/35281034/ DOI: 10.3389/fimmu.2022.790444
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards