{"id":"1b9a242f-6e4f-59c7-8f13-070308ec05c3","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-durrant-d2-white-european-alpha","predicate":"is-associated-with-within-group-negative-enrichment","statement":"The interferon-alpha response gene set was negatively enriched at week 12 versus baseline within the white-European D2 group (GSEA adjusted P≤ 0.05).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"49b74728-5b23-5727-af09-dcf1344b00ea","mechanism_event_label":"This was a time trend in a gene set within one study group, not proof of improved infection resistance.","subject":{"id":"6e1cf31c-f78e-596b-b1b3-70585cf9c948","slug":"ergocalciferol","display_name":"Ergocalciferol / vitamin D2","entity_type_key":"small_molecule"},"object":{"id":"67f2d6f3-4cdf-546f-aade-e75fa13e8037","slug":"human-blood-interferon-alpha-response-signature","display_name":"Whole-blood interferon alpha response gene-set expression","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"49b74728-5b23-5727-af09-dcf1344b00ea","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-durrant-d2-white-european-alpha-event","event_type":"observed_intervention","label":"This was a time trend in a gene set within one study group, not proof of improved infection resistance.","description":"The interferon-alpha response gene set was negatively enriched at week 12 versus baseline within the white-European D2 group (GSEA adjusted P≤ 0.05).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6e1cf31c-f78e-596b-b1b3-70585cf9c948","slug":"ergocalciferol","display_name":"Ergocalciferol / vitamin D2","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"67f2d6f3-4cdf-546f-aade-e75fa13e8037","slug":"human-blood-interferon-alpha-response-signature","display_name":"Whole-blood interferon alpha response gene-set expression","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"analysis_scope","value_text":"Within-group baseline-to-week 12 GSEA; not a randomized treatment-versus-placebo contrast.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"97 participant transcriptomic subset of Tripkovic 2017; 67 white-European and 30 South-Asian women","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"15 micrograms/day D2 or D3 or placebo for 12 winter weeks; blood microarrays at baseline/end.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Exploratory selected trial subset; differences in baseline status, season and whole-blood cell composition may matter. Within-group significance is not a significant difference between groups; no infection endpoint.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-d","display_name":"Vitamin D2 and D3","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This was a time trend in a gene set within one study group, not proof of improved infection resistance.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[durrant2022] Vitamins D2 and D3 Have Overlapping But Different Effects on the Human Immune System Revealed Through Analysis of the Blood Transcriptome. (2022). https://pubmed.ncbi.nlm.nih.gov/35281034/ DOI: 10.3389/fimmu.2022.790444","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Whole blood","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c7ca2773-5ba6-5394-9a77-b44059637f3e","evidence_kind":"source_excerpt","locator":"Lines 1128-1140","start_line":1128,"end_line":1140,"excerpt":"### vd-durrant-d2-white-european-alpha\nThe interferon-alpha response gene set was negatively enriched at week 12 versus baseline within the white-European D2 group (GSEA adjusted P≤ 0.05).\nCondition category: normal\nnutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This was a time trend in a gene set within one study group, not proof of improved infection resistance.\norganism: Homo sapiens\ntissue_or_cell_type: Whole blood\nexperimental_model: 97 participant transcriptomic subset of Tripkovic 2017; 67 white-European and 30 South-Asian women\nlimitations: Exploratory selected trial subset; differences in baseline status, season and whole-blood cell composition may matter. Within-group significance is not a significant difference between groups; no infection endpoint.\nexposure: 15 micrograms/day D2 or D3 or placebo for 12 winter weeks; blood microarrays at baseline/end.\ncross_nutrient: false\nanalysis_scope: Within-group baseline-to-week 12 GSEA; not a randomized treatment-versus-placebo contrast.\n[durrant2022] Vitamins D2 and D3 Have Overlapping But Different Effects on the Human Immune System Revealed Through Analysis of the Blood Transcriptome. (2022). https://pubmed.ncbi.nlm.nih.gov/35281034/ DOI: 10.3389/fimmu.2022.790444","model_system":"97 participant transcriptomic subset of Tripkovic 2017; 67 white-European and 30 South-Asian women","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [durrant2022] Vitamins D2 and D3 Have Overlapping But Different Effects on the Human Immune System Revealed Through Analysis of the Blood Transcriptome. (2022). https://pubmed.ncbi.nlm.nih.gov/35281034/ DOI: 10.3389/fimmu.2022.790444","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c95c763c-5b31-5b3f-a2f8-2dfe5ef0d3ca","stable_key":"import-1deb434a-3547-51a0-a038-87b1ce79ec38","title":"Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"51004bf0d78db6146b8f198b0688a3cc7d4ea9822415a9c034f4c8790fb4e38b","revision_id":"d52ff207-a311-5f24-96f4-462838792db5","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}