Component
Human right-atrial HADHA lysine acetylation
Study-specific entity. Experimental conditions and evidence limits remain on each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The five surgical atrial samples showed higher HADHA acetylation in the three obese samples, but DLAT was higher in only two of those three.
Experimental context and source evidence
- access_level
- full_text_and_supplement_review
- compartment
- Right atrial tissue lysate
- dose
- No experimental drug or nutrient exposure
- duration
- Single sampling at surgery
- endpoint
- human-atrial-hadha-acetylation
- evidence_location
- Supplementary Table S1 and Figure S20, visually inspected
- experimental_model
- Cross-sectional convenience sample: 3 obese and 2 non-obese surgical patients
- exposure
- human-obesity-cabg-samples
- limitations
- Single primary study; not independently replicated here. Cardiac and recombinant findings do not establish pulmonary endothelial, viral-sepsis or ARDS effects. Descriptive convenience sample, not a validated correlation or causal human-heart intervention. Right atrium is not left ventricle. A review response assigns an inconsistent heart-failure label; no diagnosis is inferred from that wording.
- organism
- Homo sapiens
- plain_language
- The five surgical atrial samples showed higher HADHA acetylation in the three obese samples, but DLAT was higher in only two of those three.
- primary_locator
- [{"cache": "artifacts/dlat-curation/heart-blocks.json", "block_index": 44, "text_sha256": "e0a92f47bc76c894816706ffb5158242c968928ac61e4561262c370035eda621", "xml_element_id": "Par19"}, {"cache": "artifacts/dlat-curation/heart-blocks.json", "block_index": 104, "text_sha256": "ae51373bee14359b2ba2ca7de36bd5414f6a04956020ac189c94fe8fd37ead43", "xml_element_id": "Par47"}, {"cache": "artifacts/dlat-curation/41467_2026_70703_MOESM1_ESM.pdf", "location": "Supplementary Table S1 and Figure S20", "sha256": "82754f96eebe642d7dcc3a4c7a1c9e3437da00a14aa6c7bfb67b369c5a927c90"}]
- primary_references
- https://doi.org/10.1038/s41467-026-70703-w
- sample_size
- 3 obese; 2 non-obese
- tissue_or_cell_type
- Right atrial tissue collected during CABG
DLAT: cardiac fatty-acid oxidation and mitochondrial glutathione evidence · lines 698–713
AI-assisted two-paper curation, 2026-09-20. Cardiac full-text/supplement review; CRC abstract only. No pulmonary endothelial validation. · supports · Cross-sectional convenience sample: 3 obese and 2 non-obese surgical patients · source_derived_draft · unverified_draft
The five surgical atrial samples showed higher HADHA acetylation in the three obese samples, but DLAT was higher in only two of those three. organism: Homo sapiens tissue_or_cell_type: Right atrial tissue collected during CABG experimental_model: Cross-sectional convenience sample: 3 obese and 2 non-obese surgical patients compartment: Right atrial tissue lysate dose: No experimental drug or nutrient exposure duration: Single sampling at surgery primary_references: https://doi.org/10.1038/s41467-026-70703-w access_level: full_text_and_supplement_review evidence_location: Supplementary Table S1 and Figure S20, visually inspected endpoint: human-atrial-hadha-acetylation exposure: human-obesity-cabg-samples limitations: Single primary study; not independently replicated here. Cardiac and recombinant findings do not establish pulmonary endothelial, viral-sepsis or ARDS effects. Descriptive convenience sample, not a validated correlation or causal human-heart intervention. Right atrium is not left ventricle. A review response assigns an inconsistent heart-failure label; no diagnosis is inferred from that wording. primary_locator: [{"cache": "artifacts/dlat-curation/heart-blocks.json", "block_index": 44, "text_sha256": "e0a92f47bc76c894816706ffb5158242c968928ac61e4561262c370035eda621", "xml_element_id": "Par19"}, {"cache": "artifacts/dlat-curation/heart-blocks.json", "block_index": 104, "text_sha256": "ae51373bee14359b2ba2ca7de36bd5414f6a04956020ac189c94fe8fd37ead43", "xml_element_id": "Par47"}, {"cache": "artifacts/dlat-curation/41467_2026_70703_MOESM1_ESM.pdf", "location": "Supplementary Table S1 and Figure S20", "sha256": "82754f96eebe642d7dcc3a4c7a1c9e3437da00a14aa6c7bfb67b369c5a927c90"}] plain_language: The five surgical atrial samples showed higher HADHA acetylation in the three obese samples, but DLAT was higher in only two of those three. sample_size: 3 obese; 2 non-obese
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.