{"id":"9588fdaa-4e7b-5606-8119-1481cfd8af9c","stable_key":"c156003d-8cdf-5259-8561-9803795ecc82:human-atrial-observation","predicate":"is_associated_with","statement":"The five surgical atrial samples showed higher HADHA acetylation in the three obese samples, but DLAT was higher in only two of those three.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b8702bf9-b553-516b-b68b-d4d7c7f61e05","mechanism_event_label":"human atrial observation","subject":{"id":"03250356-edb5-57c1-a240-ea774903df97","slug":"human-obesity-cabg-samples","display_name":"Obese versus non-obese CABG right-atrial tissue samples","entity_type_key":"tissue"},"object":{"id":"ffe9393e-ed1e-5579-aece-8b23ceddf5fe","slug":"human-atrial-hadha-acetylation","display_name":"Human right-atrial HADHA lysine acetylation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b8702bf9-b553-516b-b68b-d4d7c7f61e05","stable_key":"c156003d-8cdf-5259-8561-9803795ecc82:human-atrial-observation","event_type":"is_associated_with","label":"human atrial observation","description":"Model-specific finding; read linked claim context and source-access tier.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"03250356-edb5-57c1-a240-ea774903df97","slug":"human-obesity-cabg-samples","display_name":"Obese versus non-obese CABG right-atrial tissue samples","entity_type_key":"tissue"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ffe9393e-ed1e-5579-aece-8b23ceddf5fe","slug":"human-atrial-hadha-acetylation","display_name":"Human right-atrial HADHA lysine acetylation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"12e22bc4-4bc8-5a45-87bc-9274656e9dab","slug":"dlat","display_name":"Dihydrolipoyl acetyltransferase / DLAT","entity_type_key":"protein"},"role":"measured protein","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"1be55623-d714-5f38-8285-feb41ae0c655","slug":"hadha","display_name":"Human mitochondrial trifunctional protein alpha subunit / HADHA","entity_type_key":"protein"},"role":"measured protein","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"access_level","value_text":"full_text_and_supplement_review","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"compartment","value_text":"Right atrial tissue lysate","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"dose","value_text":"No experimental drug or nutrient exposure","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Single sampling at surgery","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"endpoint","value_text":"human-atrial-hadha-acetylation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Supplementary Table S1 and Figure S20, visually inspected","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cross-sectional convenience sample: 3 obese and 2 non-obese surgical patients","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"human-obesity-cabg-samples","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Single primary study; not independently replicated here. Cardiac and recombinant findings do not establish pulmonary endothelial, viral-sepsis or ARDS effects. Descriptive convenience sample, not a validated correlation or causal human-heart intervention. Right atrium is not left ventricle. A review response assigns an inconsistent heart-failure label; no diagnosis is inferred from that wording.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The five surgical atrial samples showed higher HADHA acetylation in the three obese samples, but DLAT was higher in only two of those three.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_locator","value_text":"[{\"cache\": \"artifacts/dlat-curation/heart-blocks.json\", \"block_index\": 44, \"text_sha256\": \"e0a92f47bc76c894816706ffb5158242c968928ac61e4561262c370035eda621\", \"xml_element_id\": \"Par19\"}, {\"cache\": \"artifacts/dlat-curation/heart-blocks.json\", \"block_index\": 104, \"text_sha256\": \"ae51373bee14359b2ba2ca7de36bd5414f6a04956020ac189c94fe8fd37ead43\", \"xml_element_id\": \"Par47\"}, {\"cache\": \"artifacts/dlat-curation/41467_2026_70703_MOESM1_ESM.pdf\", \"location\": \"Supplementary Table S1 and Figure S20\", \"sha256\": \"82754f96eebe642d7dcc3a4c7a1c9e3437da00a14aa6c7bfb67b369c5a927c90\"}]","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"https://doi.org/10.1038/s41467-026-70703-w","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"sample_size","value_text":"3 obese; 2 non-obese","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Right atrial tissue collected during CABG","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4b683434-a7ca-521e-a54a-7bce876bdaa4","evidence_kind":"source_excerpt","locator":"Lines 698-713","start_line":698,"end_line":713,"excerpt":"The five surgical atrial samples showed higher HADHA acetylation in the three obese samples, but DLAT was higher in only two of those three.\norganism: Homo sapiens\ntissue_or_cell_type: Right atrial tissue collected during CABG\nexperimental_model: Cross-sectional convenience sample: 3 obese and 2 non-obese surgical patients\ncompartment: Right atrial tissue lysate\ndose: No experimental drug or nutrient exposure\nduration: Single sampling at surgery\nprimary_references: https://doi.org/10.1038/s41467-026-70703-w\naccess_level: full_text_and_supplement_review\nevidence_location: Supplementary Table S1 and Figure S20, visually inspected\nendpoint: human-atrial-hadha-acetylation\nexposure: human-obesity-cabg-samples\nlimitations: Single primary study; not independently replicated here. Cardiac and recombinant findings do not establish pulmonary endothelial, viral-sepsis or ARDS effects. Descriptive convenience sample, not a validated correlation or causal human-heart intervention. Right atrium is not left ventricle. A review response assigns an inconsistent heart-failure label; no diagnosis is inferred from that wording.\nprimary_locator: [{\"cache\": \"artifacts/dlat-curation/heart-blocks.json\", \"block_index\": 44, \"text_sha256\": \"e0a92f47bc76c894816706ffb5158242c968928ac61e4561262c370035eda621\", \"xml_element_id\": \"Par19\"}, {\"cache\": \"artifacts/dlat-curation/heart-blocks.json\", \"block_index\": 104, \"text_sha256\": \"ae51373bee14359b2ba2ca7de36bd5414f6a04956020ac189c94fe8fd37ead43\", \"xml_element_id\": \"Par47\"}, {\"cache\": \"artifacts/dlat-curation/41467_2026_70703_MOESM1_ESM.pdf\", \"location\": \"Supplementary Table S1 and Figure S20\", \"sha256\": \"82754f96eebe642d7dcc3a4c7a1c9e3437da00a14aa6c7bfb67b369c5a927c90\"}]\nplain_language: The five surgical atrial samples showed higher HADHA acetylation in the three obese samples, but DLAT was higher in only two of those three.\nsample_size: 3 obese; 2 non-obese","model_system":"Cross-sectional convenience sample: 3 obese and 2 non-obese surgical patients","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Quotation is the authored curation, not original publisher wording. Exact primary locators and access limits retained in contexts.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"ee72956d-4fd4-58d3-9a94-e173bb1e3282","stable_key":"import-c156003d-8cdf-5259-8561-9803795ecc82","title":"DLAT: cardiac fatty-acid oxidation and mitochondrial glutathione evidence","document_type":"imported_text","citation_label":"AI-assisted two-paper curation, 2026-09-20. Cardiac full-text/supplement review; CRC abstract only. No pulmonary endothelial validation.","file_path":"","sha256":"159e5472c8b1d104625f9c648dc9ee24dcd5fe102109fd960bba50e9ba9de954","revision_id":"5ca6b1f1-fd75-5f8d-ba2b-0215fbf387c7","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}