Component
Human ALDOB Arg303Trp variant
Variant numbering follows the original report; impaired fructose-1-phosphate activity is demonstrated in recombinant protein.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The human ALDOB Arg303Trp variant had no detectable fructose-1-phosphate activity in the reported assay.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- dose
- Wild-type versus hereditary-fructose-intolerance-associated variants; exact substrate series not in abstract
- duration
- Assay duration not recovered
- evidence_access
- Primary abstract/metadata; unrecovered methods explicitly retained.
- evidence_scope
- literature_reviewed; source-specific curation
- experimental_model
- Recombinant wild-type and Arg303Trp human ALDOB
- exposure_scope
- Human genetic machinery / fructose component
- limitations
- A mutation-specific activity defect is not ordinary dietary intolerance or a population toxicity threshold. Full article is scanned; abstract kinetics used.
- nutrient_topic
- HFCS chapter: actual formulation studies, component biochemistry and interventions are explicitly distinguished. · High-Fructose Corn Syrup / HFCS
- organism
- Recombinant wild-type and Arg303Trp human ALDOB
- plain_language
- The human ALDOB Arg303Trp variant had no detectable fructose-1-phosphate activity in the reported assay.
- primary_references
- Functional and molecular modelling studies of two hereditary fructose intolerance-causing mutations at arginine 303 in human liver aldolase. (2000). https://pubmed.ncbi.nlm.nih.gov/10970798/
- route
- In vitro recombinant enzyme assay
- tissue
- Fructose-1-phosphate enzyme assay
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
High-Fructose Corn Syrup: mechanism of action and metabolic impact (2026-09-20) · lines 125–135
Original AI-assisted curation of twenty primary studies and official FDA composition information, with one reused canonical glucose-transport claim. Study-specific citations, negative findings and limitations retained. Not publisher full text. · supports · Recombinant wild-type and Arg303Trp human ALDOB · source_derived_draft · unverified_draft
## hfcs-aldob-variant The human ALDOB Arg303Trp variant had no detectable fructose-1-phosphate activity in the reported assay. Model/species: Recombinant wild-type and Arg303Trp human ALDOB Tissue: Fructose-1-phosphate enzyme assay Exposure: Wild-type versus hereditary-fructose-intolerance-associated variants; exact substrate series not in abstract Route: In vitro recombinant enzyme assay Duration: Assay duration not recovered Exposure scope: Human genetic machinery / fructose component Limits: A mutation-specific activity defect is not ordinary dietary intolerance or a population toxicity threshold. Full article is scanned; abstract kinetics used. Reference: Functional and molecular modelling studies of two hereditary fructose intolerance-causing mutations at arginine 303 in human liver aldolase. (2000). https://pubmed.ncbi.nlm.nih.gov/10970798/ Access: Primary abstract/metadata; unrecovered methods explicitly retained.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.