Component
Endothelial-function endpoint in the optimized aged black garlic trial
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The same trial found no change in measured endothelial function or inflammatory cytokines.
Experimental context and source evidence
- acting_entity
- optimized-aged-black-garlic-2023
- dose
- Optimized aged black garlic extract providing 0.25 mg SAC/day
- duration
- Twelve weeks
- evidence_access
- Primary abstract
- experimental_comparison
- Randomized triple-blind placebo-controlled extract trial
- experimental_model
- Grade I hypertensive participants receiving antihypertensive treatment
- interpretation_status
- Source-derived research curation; not independent primary verification
- limitations
- Null endpoints coexist with other reported changes; no universal vascular improvement is inferred.
- nutrient_topic
- S-allylcysteine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · S-allyl-L-cysteine / SAC
- organism
- Homo sapiens
- plain_language
- The formulation did not improve every measured endpoint.
- primary_references
- [37686723] Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37686723/ · DOI 10.3390/nu15173691
- route
- Oral
- tissue_or_cell_type
- Grade I hypertensive participants receiving antihypertensive treatment
S-allylcysteine: sulfur signaling, redox responses and cross-nutrient mechanisms (2026-09-20) · lines 446–453
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Grade I hypertensive participants receiving antihypertensive treatment · source_derived_draft · unverified_draft
## s-allylcysteine-extract-endothelial-null The formulation did not improve every measured endpoint. The same trial found no change in measured endothelial function or inflammatory cytokines. Model: Grade I hypertensive participants receiving antihypertensive treatment Limitations: Null endpoints coexist with other reported changes; no universal vascular improvement is inferred. Evidence access: Primary abstract [37686723] Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37686723/ · DOI 10.3390/nu15173691 Structured context: {"organism": "Homo sapiens", "tissue_or_cell_type": "Grade I hypertensive participants receiving antihypertensive treatment", "dose": "Optimized aged black garlic extract providing 0.25 mg SAC/day", "duration": "Twelve weeks", "route": "Oral", "experimental_comparison": "Randomized triple-blind placebo-controlled extract trial", "acting_entity": "optimized-aged-black-garlic-2023", "interpretation_status": "Source-derived research curation; not independent primary verification"}
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.