{"id":"bfcf1e7e-27fa-53f6-a88e-56965abe52e8","stable_key":"d96b230c-481b-535b-930c-04eb87ec7f02:s-allylcysteine-extract-endothelial-null","predicate":"does_not_change_tested","statement":"The same trial found no change in measured endothelial function or inflammatory cytokines.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"17d36b58-50b0-5562-bc49-f5b7b4212f43","mechanism_event_label":"The formulation did not improve every measured endpoint.","subject":{"id":"13629967-abbc-5be1-a2b4-1f25eb3368f1","slug":"optimized-aged-black-garlic-2023","display_name":"Optimized aged black garlic extract in the 2023 hypertension trial","entity_type_key":"chemical_species"},"object":{"id":"2456d8f5-5608-5168-b831-08aa170e1909","slug":"human-aged-garlic-endothelial-function","display_name":"Endothelial-function endpoint in the optimized aged black garlic trial","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"17d36b58-50b0-5562-bc49-f5b7b4212f43","stable_key":"d96b230c-481b-535b-930c-04eb87ec7f02:s-allylcysteine-extract-endothelial-null-event","event_type":"observed_relationship","label":"The formulation did not improve every measured endpoint.","description":"The same trial found no change in measured endothelial function or inflammatory cytokines.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"13629967-abbc-5be1-a2b4-1f25eb3368f1","slug":"optimized-aged-black-garlic-2023","display_name":"Optimized aged black garlic extract in the 2023 hypertension trial","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2456d8f5-5608-5168-b831-08aa170e1909","slug":"human-aged-garlic-endothelial-function","display_name":"Endothelial-function endpoint in the optimized aged black garlic trial","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"acting_entity","value_text":"optimized-aged-black-garlic-2023","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"dose","value_text":"Optimized aged black garlic extract providing 0.25 mg SAC/day","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Twelve weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_comparison","value_text":"Randomized triple-blind placebo-controlled extract trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Grade I hypertensive participants receiving antihypertensive treatment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived research curation; 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no universal vascular improvement is inferred.\nEvidence access: Primary abstract\n[37686723] Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37686723/ · DOI 10.3390/nu15173691\nStructured context: {\"organism\": \"Homo sapiens\", \"tissue_or_cell_type\": \"Grade I hypertensive participants receiving antihypertensive treatment\", \"dose\": \"Optimized aged black garlic extract providing 0.25 mg SAC/day\", \"duration\": \"Twelve weeks\", \"route\": \"Oral\", \"experimental_comparison\": \"Randomized triple-blind placebo-controlled extract trial\", \"acting_entity\": \"optimized-aged-black-garlic-2023\", \"interpretation_status\": \"Source-derived research curation; not independent primary verification\"}","model_system":"Grade I hypertensive participants receiving antihypertensive treatment","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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