Component
ATPase activity of recombinant human ABCB1 / P-glycoprotein
Experimental model, exposure and limitations remain on each linked record.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Tartrazine did not stimulate P-glycoprotein-specific ATPase activity in the membrane assay.
Experimental context and source evidence
- dose
- Tartrazine 0.41-900 micromolar; verapamil and orthovanadate controls
- duration
- Manufacturer ATPase assay interval not stated in accessed methods
- evidence_access
- Primary full-text methods/results and metadata.
- evidence_scope
- literature_reviewed; source-specific experimental curation
- experimental_model
- Recombinant human P-glycoprotein in membrane preparations
- limitations
- A negative ATPase-stimulation result is bounded by the assay and does not establish universal lack of transport interactions.
- nutrient_topic
- Tartrazine food-colorant chapter; nutrient, drug and peptide interactions retain their models and limits. · Tartrazine
- organism
- Recombinant human P-glycoprotein in membrane preparations
- plain_language
- Tartrazine did not stimulate P-glycoprotein-specific ATPase activity in the membrane assay.
- primary_references
- Food dyes as P-glycoprotein modulators. (2020). https://pubmed.ncbi.nlm.nih.gov/33011351/ DOI: 10.1016/j.fct.2020.111785
- route
- In vitro membrane assay
- tissue
- ATPase stimulation assay
Tartrazine: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 226–235
Original AI-assisted curation of eighteen primary studies. Study-specific citations, negative findings and limitations retained. Not publisher full text. · supports · Recombinant human P-glycoprotein in membrane preparations · source_derived_draft · unverified_draft
## tartrazine-pgp-atpase-null Tartrazine did not stimulate P-glycoprotein-specific ATPase activity in the membrane assay. Model/species: Recombinant human P-glycoprotein in membrane preparations Tissue: ATPase stimulation assay Exposure: Tartrazine 0.41-900 micromolar; verapamil and orthovanadate controls Route: In vitro membrane assay Duration: Manufacturer ATPase assay interval not stated in accessed methods Limits: A negative ATPase-stimulation result is bounded by the assay and does not establish universal lack of transport interactions. Primary reference: Food dyes as P-glycoprotein modulators. (2020). https://pubmed.ncbi.nlm.nih.gov/33011351/ DOI: 10.1016/j.fct.2020.111785 Access: Primary full-text methods/results and metadata.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.