Component
Etoposide-associated cytotoxicity in human HL-60 cells
Etoposide-associated cytotoxicity in human HL-60 cells. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Mangiferin did not attenuate etoposide cytotoxicity in HL-60 cells, despite protecting cord-blood mononuclear cells in the comparison.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/mangiferin-research/24374812.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "85ad69fcef2b1dd7b3842c076b89b76c9d54b73cc5843cefb3077642b6cb3451", "start_char": 0, "end_char": 1789, "text_sha256": "85ad69fcef2b1dd7b3842c076b89b76c9d54b73cc5843cefb3077642b6cb3451"}
- experimental_model
- Cell-line and primary mononuclear-cell comparison
- exposure
- Mangiferin 50 micromolar in principal assays; etoposide co-exposure
- limitations
- No clinical chemotherapy outcome. The abstract has an inconsistent mol/L unit in a later sentence; the 50 micromolar experimental concentration is explicit earlier.
- nutrient_topic
- Mangiferin research collection; topical membership is not evidence of a direct dietary effect. · Mangiferin
- organism
- Homo sapiens
- plain_language
- Protection varied with cell type.
- primary_references
- [mangiferin-p24374812] Mangiferin activates Nrf2-antioxidant response element signaling without reducing the sensitivity to etoposide of human myeloid leukemia cells in vitro. (2014). https://pubmed.ncbi.nlm.nih.gov/24374812/ DOI: 10.1038/aps.2013.165
- tissue_or_cell_type
- HL-60 leukemia cells and cord-blood mononuclear cells
Mangiferin: metabolism, signaling and nutrient connections (2026-09-17) · lines 1303–1314
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cell-line and primary mononuclear-cell comparison · source_derived_draft · unverified_draft
### mangiferin-etoposide-cell-context Mangiferin did not attenuate etoposide cytotoxicity in HL-60 cells, despite protecting cord-blood mononuclear cells in the comparison. Condition category: normal nutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Protection varied with cell type. organism: Homo sapiens tissue_or_cell_type: HL-60 leukemia cells and cord-blood mononuclear cells experimental_model: Cell-line and primary mononuclear-cell comparison limitations: No clinical chemotherapy outcome. The abstract has an inconsistent mol/L unit in a later sentence; the 50 micromolar experimental concentration is explicit earlier. exposure: Mangiferin 50 micromolar in principal assays; etoposide co-exposure evidence_span: {"source_cache": "artifacts/mangiferin-research/24374812.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "85ad69fcef2b1dd7b3842c076b89b76c9d54b73cc5843cefb3077642b6cb3451", "start_char": 0, "end_char": 1789, "text_sha256": "85ad69fcef2b1dd7b3842c076b89b76c9d54b73cc5843cefb3077642b6cb3451"} [mangiferin-p24374812] Mangiferin activates Nrf2-antioxidant response element signaling without reducing the sensitivity to etoposide of human myeloid leukemia cells in vitro. (2014). https://pubmed.ncbi.nlm.nih.gov/24374812/ DOI: 10.1038/aps.2013.165
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.