Component
Hippocampal neuronal damage after prolonged THC exposure
Hippocampal neuronal damage after prolonged THC exposure. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Prolonged THC administration produced hippocampal neurotoxicity in rats.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/thc-research/9651215.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8e38fbb1327a18b89adb1a015aa7f59e7e60472a5f19bcf4032dbd2ba827be60", "start_char": 0, "end_char": 974, "text_sha256": "8e38fbb1327a18b89adb1a015aa7f59e7e60472a5f19bcf4032dbd2ba827be60"}
- experimental_model
- Prolonged THC administration with hippocampal histology
- exposure
- Chronic high-dose THC exposure
- limitations
- A structural damage endpoint at high chronic doses in rats. The doses are far above ordinary human exposure, which is the main limit on reading it across.
- nutrient_topic
- THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
- organism
- Rat
- plain_language
- At high chronic doses in rats the same structure shows physical damage.
- primary_references
- [thc-p9651215] Hippocampal neurotoxicity of Delta9-tetrahydrocannabinol. (1998). https://pubmed.ncbi.nlm.nih.gov/9651215/ DOI: 10.1523/jneurosci.18-14-05322.1998
- tissue_or_cell_type
- Hippocampus
THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 478–489
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Prolonged THC administration with hippocampal histology · source_derived_draft · unverified_draft
### thc-thc-hippocampal-damage Prolonged THC administration produced hippocampal neurotoxicity in rats. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: At high chronic doses in rats the same structure shows physical damage. organism: Rat tissue_or_cell_type: Hippocampus experimental_model: Prolonged THC administration with hippocampal histology limitations: A structural damage endpoint at high chronic doses in rats. The doses are far above ordinary human exposure, which is the main limit on reading it across. exposure: Chronic high-dose THC exposure evidence_span: {"source_cache": "artifacts/thc-research/9651215.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8e38fbb1327a18b89adb1a015aa7f59e7e60472a5f19bcf4032dbd2ba827be60", "start_char": 0, "end_char": 974, "text_sha256": "8e38fbb1327a18b89adb1a015aa7f59e7e60472a5f19bcf4032dbd2ba827be60"} [thc-p9651215] Hippocampal neurotoxicity of Delta9-tetrahydrocannabinol. (1998). https://pubmed.ncbi.nlm.nih.gov/9651215/ DOI: 10.1523/jneurosci.18-14-05322.1998
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.