{"id":"ae531b12-a7ff-5d1b-8e72-f48487eefa84","stable_key":"05a3cf47-e660-5ab3-8c32-5eba9847cf0a:thc-thc-hippocampal-damage","predicate":"causes","statement":"Prolonged THC administration produced hippocampal neurotoxicity in rats.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"0e9ebc11-de8b-54d0-a719-7ef8cf9b6489","mechanism_event_label":"At high chronic doses in rats the same structure shows physical damage.","subject":{"id":"5a9e5b75-e6aa-5684-ad62-8a8d60148c84","slug":"tetrahydrocannabinol","display_name":"Delta-9-tetrahydrocannabinol / THC","entity_type_key":"drug"},"object":{"id":"6d2b1666-bcdd-54f8-a909-2120f2d006f9","slug":"hippocampal-neurotoxicity","display_name":"Hippocampal neuronal damage after prolonged THC exposure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0e9ebc11-de8b-54d0-a719-7ef8cf9b6489","stable_key":"05a3cf47-e660-5ab3-8c32-5eba9847cf0a:thc-thc-hippocampal-damage-event","event_type":"biochemical_relationship","label":"At high chronic doses in rats the same structure shows physical damage.","description":"Prolonged THC administration produced hippocampal neurotoxicity in rats.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5a9e5b75-e6aa-5684-ad62-8a8d60148c84","slug":"tetrahydrocannabinol","display_name":"Delta-9-tetrahydrocannabinol / THC","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6d2b1666-bcdd-54f8-a909-2120f2d006f9","slug":"hippocampal-neurotoxicity","display_name":"Hippocampal neuronal damage after prolonged THC exposure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/thc-research/9651215.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8e38fbb1327a18b89adb1a015aa7f59e7e60472a5f19bcf4032dbd2ba827be60\", \"start_char\": 0, \"end_char\": 974, \"text_sha256\": \"8e38fbb1327a18b89adb1a015aa7f59e7e60472a5f19bcf4032dbd2ba827be60\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Prolonged THC administration with hippocampal histology","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Chronic high-dose THC exposure","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A structural damage endpoint at high chronic doses in rats. The doses are far above ordinary human exposure, which is the main limit on reading it across.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates.","comparator":null,"unit":null,"notes":"","entity":{"slug":"tetrahydrocannabinol","display_name":"Delta-9-tetrahydrocannabinol / THC","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Rat","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"At high chronic doses in rats the same structure shows physical damage.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[thc-p9651215] Hippocampal neurotoxicity of Delta9-tetrahydrocannabinol. 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The doses are far above ordinary human exposure, which is the main limit on reading it across.\nexposure: Chronic high-dose THC exposure\nevidence_span: {\"source_cache\": \"artifacts/thc-research/9651215.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8e38fbb1327a18b89adb1a015aa7f59e7e60472a5f19bcf4032dbd2ba827be60\", \"start_char\": 0, \"end_char\": 974, \"text_sha256\": \"8e38fbb1327a18b89adb1a015aa7f59e7e60472a5f19bcf4032dbd2ba827be60\"}\n[thc-p9651215] Hippocampal neurotoxicity of Delta9-tetrahydrocannabinol. (1998). https://pubmed.ncbi.nlm.nih.gov/9651215/ DOI: 10.1523/jneurosci.18-14-05322.1998","model_system":"Prolonged THC administration with hippocampal histology","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [thc-p9651215] Hippocampal neurotoxicity of Delta9-tetrahydrocannabinol. 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