Component
Hepatic microsomal oxidative capacity measured by the aminopyrine breath test
Hepatic microsomal oxidative capacity measured by the aminopyrine breath test. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
In eight patients, cimetidine lowered the one-hour specific activity in the aminopyrine breath test and increased the maximum serum concentration of mebendazole, with a significant correlation between the breath test activity and the highest mebendazole concentration both before and after cimetidine, and combined administration resulted in the complete resolution of previously unresponsive hydatid cysts.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/mebendazole-research/3663452.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9bfd138da23825906ffca0d38a5a884ac761cf028ae3e0c3ddeabcc24d1c316e", "start_char": 0, "end_char": 912, "text_sha256": "9bfd138da23825906ffca0d38a5a884ac761cf028ae3e0c3ddeabcc24d1c316e"}
- experimental_model
- Aminopyrine breath test and serum mebendazole concentrations in eight patients before and after 30 days of cimetidine
- exposure
- Mebendazole 1.5 grams three times daily, with cimetidine 400 milligrams three times daily for 30 days
- limitations
- Eight patients, five of whom had peptic ulcer rather than the target disease. The resolution of previously unresponsive cysts is reported without a control.
- nutrient_topic
- Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms. · Mebendazole
- organism
- Human
- plain_language
- Blocking the liver enzyme that destroys it raises the blood level enough to clear cysts that had not responded.
- primary_references
- [mbz-p3663452] Cimetidine increases serum mebendazole concentrations. Implications for treatment of hepatic hydatid cysts. (1987). https://pubmed.ncbi.nlm.nih.gov/3663452/ DOI: 10.1111/j.1365-2125.1987.tb03186.x
- tissue_or_cell_type
- Liver and plasma
- trigger_kind
- biomarker_context Imported condition classification; unverified.
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Aminopyrine breath test and serum mebendazole concentrations in eight patients before and after 30 days of cimetidine · source_derived_draft · unverified_draft
### mbz-cimetidine-raises-levels In eight patients, cimetidine lowered the one-hour specific activity in the aminopyrine breath test and increased the maximum serum concentration of mebendazole, with a significant correlation between the breath test activity and the highest mebendazole concentration both before and after cimetidine, and combined administration resulted in the complete resolution of previously unresponsive hydatid cysts. Condition category: biomarker_context nutrient_topic: Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms. plain_language: Blocking the liver enzyme that destroys it raises the blood level enough to clear cysts that had not responded. organism: Human tissue_or_cell_type: Liver and plasma experimental_model: Aminopyrine breath test and serum mebendazole concentrations in eight patients before and after 30 days of cimetidine limitations: Eight patients, five of whom had peptic ulcer rather than the target disease. The resolution of previously unresponsive cysts is reported without a control. exposure: Mebendazole 1.5 grams three times daily, with cimetidine 400 milligrams three times daily for 30 days evidence_span: {"source_cache": "artifacts/mebendazole-research/3663452.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9bfd138da23825906ffca0d38a5a884ac761cf028ae3e0c3ddeabcc24d1c316e", "start_char": 0, "end_char": 912, "text_sha256": "9bfd138da23825906ffca0d38a5a884ac761cf028ae3e0c3ddeabcc24d1c316e"} [mbz-p3663452] Cimetidine increases serum mebendazole concentrations. Implications for treatment of hepatic hydatid cysts. (1987). https://pubmed.ncbi.nlm.nih.gov/3663452/ DOI: 10.1111/j.1365-2125.1987.tb03186.x
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.