Component
Liver glycogen concentration
Liver glycogen concentration. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The 0.2 g acetic acid group had significantly greater liver and gastrocnemius muscle glycogen concentration than the control group, and the authors concluded that a diet containing acetic acid may enhance glycogen repletion in liver and skeletal muscle.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/acetate-research/11435516.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "130bbe406429175feedf86bcfa4597f8f7f81ac1d27a5d299efc545e3225175e", "start_char": 0, "end_char": 1638, "text_sha256": "130bbe406429175feedf86bcfa4597f8f7f81ac1d27a5d299efc545e3225175e"}
- experimental_model
- Food-deprived rats given graded dietary acetic acid for 2 hours
- exposure
- 0, 0.1, 0.2 or 0.4 g acetic acid per 100 g diet for 2 hours after 15 hours of food deprivation
- limitations
- Only the 0.2 g dose reached significance for glycogen, so the dose-response is not monotonic. The glycolytic mechanism is the authors’ inference from metabolite ratios, not a direct enzyme measurement.
- nutrient_topic
- Acetic acid research collection; topical membership is not evidence of a direct clinical effect, and the ingested acid is recorded separately from the circulating acetate anion. · Acetic acid
- organism
- Rat
- plain_language
- A small dose of the acid helped both the liver and the muscle refill their glucose stores.
- primary_references
- [acetate-p11435516] Acetic acid feeding enhances glycogen repletion in liver and skeletal muscle of rats. (2001). https://pubmed.ncbi.nlm.nih.gov/11435516/ DOI: 10.1093/jn/131.7.1973
- tissue_or_cell_type
- Liver and skeletal muscle
Acetic acid: the ingested acid, the receptors acetate binds, the acetyl-CoA it becomes, and the acetyl groups that reach histones (2026-09-21) · lines 433–444
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Food-deprived rats given graded dietary acetic acid for 2 hours · source_derived_draft · unverified_draft
### acetate-acetate-glycogen The 0.2 g acetic acid group had significantly greater liver and gastrocnemius muscle glycogen concentration than the control group, and the authors concluded that a diet containing acetic acid may enhance glycogen repletion in liver and skeletal muscle. Condition category: normal nutrient_topic: Acetic acid research collection; topical membership is not evidence of a direct clinical effect, and the ingested acid is recorded separately from the circulating acetate anion. plain_language: A small dose of the acid helped both the liver and the muscle refill their glucose stores. organism: Rat tissue_or_cell_type: Liver and skeletal muscle experimental_model: Food-deprived rats given graded dietary acetic acid for 2 hours limitations: Only the 0.2 g dose reached significance for glycogen, so the dose-response is not monotonic. The glycolytic mechanism is the authors’ inference from metabolite ratios, not a direct enzyme measurement. exposure: 0, 0.1, 0.2 or 0.4 g acetic acid per 100 g diet for 2 hours after 15 hours of food deprivation evidence_span: {"source_cache": "artifacts/acetate-research/11435516.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "130bbe406429175feedf86bcfa4597f8f7f81ac1d27a5d299efc545e3225175e", "start_char": 0, "end_char": 1638, "text_sha256": "130bbe406429175feedf86bcfa4597f8f7f81ac1d27a5d299efc545e3225175e"} [acetate-p11435516] Acetic acid feeding enhances glycogen repletion in liver and skeletal muscle of rats. (2001). https://pubmed.ncbi.nlm.nih.gov/11435516/ DOI: 10.1093/jn/131.7.1973
Complete structured claim and evidence
Where it participates (unsigned role)
At 4 hours after the start of feeding the acetic acid group had significantly greater liver and gastrocnemius muscle glycogen concentrations, and the authors concluded that a diet containing acetic acid may enhance glycogen repletion but not induce supercompensation, the large increase in glycogen that is beneficial in improving performance, by transitory inhibition of glycolysis.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/acetate-research/16277773.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "305aa81aca9908a350132a7c7dcc42c86be0b6030c70f51b5fe0c8971e75bcfe", "start_char": 0, "end_char": 1594, "text_sha256": "305aa81aca9908a350132a7c7dcc42c86be0b6030c70f51b5fe0c8971e75bcfe"}
- experimental_model
- Rats meal-fed once daily for 10 days, then sampled 4, 8 or 24 hours after feeding
- exposure
- 0.7 g/kg-diet acetic acid in a 9 g meal, with sampling across the daily cycle
- limitations
- Adds the time dimension that single-timepoint studies miss. The effects were present at 4 hours and the authors explicitly rule out supercompensation.
- nutrient_topic
- Acetic acid research collection; topical membership is not evidence of a direct clinical effect, and the ingested acid is recorded separately from the circulating acetate anion. · Acetic acid
- organism
- Rat
- plain_language
- The stores refill faster but do not overfill, so this is not carbohydrate loading.
- primary_references
- [acetate-p16277773] Effect of acetic acid feeding on the circadian changes in glycogen and metabolites of glucose and lipid in liver and skeletal muscle of rats. (2005). https://pubmed.ncbi.nlm.nih.gov/16277773/ DOI: 10.1079/bjn20051545
- tissue_or_cell_type
- Liver and skeletal muscle
Acetic acid: the ingested acid, the receptors acetate binds, the acetyl-CoA it becomes, and the acetyl groups that reach histones (2026-09-21) · lines 459–470
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rats meal-fed once daily for 10 days, then sampled 4, 8 or 24 hours after feeding · source_derived_draft · unverified_draft
### acetate-no-supercompensation At 4 hours after the start of feeding the acetic acid group had significantly greater liver and gastrocnemius muscle glycogen concentrations, and the authors concluded that a diet containing acetic acid may enhance glycogen repletion but not induce supercompensation, the large increase in glycogen that is beneficial in improving performance, by transitory inhibition of glycolysis. Condition category: normal nutrient_topic: Acetic acid research collection; topical membership is not evidence of a direct clinical effect, and the ingested acid is recorded separately from the circulating acetate anion. plain_language: The stores refill faster but do not overfill, so this is not carbohydrate loading. organism: Rat tissue_or_cell_type: Liver and skeletal muscle experimental_model: Rats meal-fed once daily for 10 days, then sampled 4, 8 or 24 hours after feeding limitations: Adds the time dimension that single-timepoint studies miss. The effects were present at 4 hours and the authors explicitly rule out supercompensation. exposure: 0.7 g/kg-diet acetic acid in a 9 g meal, with sampling across the daily cycle evidence_span: {"source_cache": "artifacts/acetate-research/16277773.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "305aa81aca9908a350132a7c7dcc42c86be0b6030c70f51b5fe0c8971e75bcfe", "start_char": 0, "end_char": 1594, "text_sha256": "305aa81aca9908a350132a7c7dcc42c86be0b6030c70f51b5fe0c8971e75bcfe"} [acetate-p16277773] Effect of acetic acid feeding on the circadian changes in glycogen and metabolites of glucose and lipid in liver and skeletal muscle of rats. (2005). https://pubmed.ncbi.nlm.nih.gov/16277773/ DOI: 10.1079/bjn20051545
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.