Component
Hepatic gluconeogenic flux
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The estimated gluconeogenic fraction of glucose production increased from 36% overnight to 78% after 60 hours.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Human stable-isotope study of fasting and hepatic UDP-glucose flux.
- limitations
- Tracer duration and glycogen cycling affect fractional estimates; a percentage is not an absolute production rate.
- nutrient_topic
- Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished. · Fasting / abstention from energy intake
- plain_language
- New glucose production increasingly replaced stored carbohydrate.
- primary_references
- Hepatic gluconeogenic fluxes and glycogen turnover during fasting in humans. A stable isotope study. · 1997 · https://pubmed.ncbi.nlm.nih.gov/9276749/ · DOI 10.1172/JCI119644
Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18) · lines 64–70
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human stable-isotope study of fasting and hepatic UDP-glucose flux. · source_derived_draft · unverified_draft
## fast-gluconeogenesis New glucose production increasingly replaced stored carbohydrate. The estimated gluconeogenic fraction of glucose production increased from 36% overnight to 78% after 60 hours. Model: Human stable-isotope study of fasting and hepatic UDP-glucose flux. Limitations: Tracer duration and glycogen cycling affect fractional estimates; a percentage is not an absolute production rate. Evidence access: Primary abstract Hepatic gluconeogenic fluxes and glycogen turnover during fasting in humans. A stable isotope study. · 1997 · https://pubmed.ncbi.nlm.nih.gov/9276749/ · DOI 10.1172/JCI119644
Complete structured claim and evidence
Where it participates (unsigned role)
At 60 hours, glycogen-derived plasma glucose flux of 0.32 mg/kg/min was balanced by 0.31 mg/kg/min retained gluconeogenic carbon.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Human isotope model; 60-hour fast.
- limitations
- Does not support a fixed time when all glycogen becomes empty.
- nutrient_topic
- Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished. · Fasting / abstention from energy intake
- plain_language
- The liver still cycled carbon through glycogen.
- primary_references
- Hepatic gluconeogenic fluxes and glycogen turnover during fasting in humans. A stable isotope study. · 1997 · https://pubmed.ncbi.nlm.nih.gov/9276749/ · DOI 10.1172/JCI119644
Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18) · lines 72–78
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human isotope model; 60-hour fast. · source_derived_draft · unverified_draft
## fast-glycogen-cycle The liver still cycled carbon through glycogen. At 60 hours, glycogen-derived plasma glucose flux of 0.32 mg/kg/min was balanced by 0.31 mg/kg/min retained gluconeogenic carbon. Model: Human isotope model; 60-hour fast. Limitations: Does not support a fixed time when all glycogen becomes empty. Evidence access: Primary abstract Hepatic gluconeogenic fluxes and glycogen turnover during fasting in humans. A stable isotope study. · 1997 · https://pubmed.ncbi.nlm.nih.gov/9276749/ · DOI 10.1172/JCI119644
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.