{"id":"aa4f1c2c-d430-5bed-aea3-e53503546486","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-gluconeogenesis","predicate":"increases_fractional_contribution","statement":"The estimated gluconeogenic fraction of glucose production increased from 36% overnight to 78% after 60 hours.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"84fc09c0-5a01-53df-8279-c21917d68600","mechanism_event_label":"New glucose production increasingly replaced stored carbohydrate.","subject":{"id":"2d5df4b9-44d7-56a5-8ecf-7c08c0ae9f4f","slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"},"object":{"id":"9a6a629b-c2e0-5516-9202-e0b8e4570b66","slug":"hepatic-gluconeogenic-flux","display_name":"Hepatic gluconeogenic flux","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"84fc09c0-5a01-53df-8279-c21917d68600","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-gluconeogenesis-event","event_type":"observed_relationship","label":"New glucose production increasingly replaced stored carbohydrate.","description":"The estimated gluconeogenic fraction of glucose production increased from 36% overnight to 78% after 60 hours.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2d5df4b9-44d7-56a5-8ecf-7c08c0ae9f4f","slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9a6a629b-c2e0-5516-9202-e0b8e4570b66","slug":"hepatic-gluconeogenic-flux","display_name":"Hepatic gluconeogenic flux","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human stable-isotope study of fasting and hepatic UDP-glucose flux.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Tracer duration and glycogen cycling affect fractional estimates; a percentage is not an absolute production rate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"New glucose production increasingly replaced stored carbohydrate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Hepatic gluconeogenic fluxes and glycogen turnover during fasting in humans. A stable isotope study. · 1997 · https://pubmed.ncbi.nlm.nih.gov/9276749/ · DOI 10.1172/JCI119644","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e1b4d793-ad3a-5a39-b93e-f0c1e9c844e3","evidence_kind":"source_excerpt","locator":"Lines 64-70","start_line":64,"end_line":70,"excerpt":"## fast-gluconeogenesis\nNew glucose production increasingly replaced stored carbohydrate.\nThe estimated gluconeogenic fraction of glucose production increased from 36% overnight to 78% after 60 hours.\nModel: Human stable-isotope study of fasting and hepatic UDP-glucose flux.\nLimitations: Tracer duration and glycogen cycling affect fractional estimates; a percentage is not an absolute production rate.\nEvidence access: Primary abstract\nHepatic gluconeogenic fluxes and glycogen turnover during fasting in humans. A stable isotope study. · 1997 · https://pubmed.ncbi.nlm.nih.gov/9276749/ · DOI 10.1172/JCI119644","model_system":"Human stable-isotope study of fasting and hepatic UDP-glucose flux.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"991b7fd94be84c0f1e622e0672eda03d600b388dfd7825e219aa1678d1c7983a","revision_id":"ce85d3f4-4eaf-5aee-bddb-0f0ce7fe2211","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}