Component
Major adverse cardiovascular events in heart failure
Major adverse cardiovascular events in heart failure. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Two-year major adverse events occurred in 15% on CoQ versus 26% on placebo, hazard ratio 0.50 (95% CI 0.32-0.80).
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/coq10-research/25282031.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "20ff9f86de1fab16a33ecadfb2c4e09e9017860f01854cfecf490d473fb8fb65", "start_char": 0, "end_char": 2024, "text_sha256": "20ff9f86de1fab16a33ecadfb2c4e09e9017860f01854cfecf490d473fb8fb65"}
- experimental_model
- Q-SYMBIO randomized double-blind multicenter trial
- exposure
- 100 mg CoQ10 three times daily added to standard therapy
- limitations
- One adjunctive-treatment trial; recruitment preceded current heart-failure regimens. Does not show universal benefit or replacement of standard treatment.
- nutrient_topic
- Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. · Coenzyme Q10 / CoQ10 redox system
- organism
- 420 patients with moderate-to-severe chronic heart failure
- plain_language
- This trial found a benefit on clinical events when CoQ was added to usual care.
- primary_references
- [coq10-p25282031] The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. (2014). https://pubmed.ncbi.nlm.nih.gov/25282031/ DOI: 10.1016/j.jchf.2014.06.008
- tissue_or_cell_type
- Short-term function and two-year clinical events
Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17) · lines 1087–1098
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Q-SYMBIO randomized double-blind multicenter trial · source_derived_draft · unverified_draft
### coq10-heart-failure-events Two-year major adverse events occurred in 15% on CoQ versus 26% on placebo, hazard ratio 0.50 (95% CI 0.32-0.80). Condition category: normal nutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. plain_language: This trial found a benefit on clinical events when CoQ was added to usual care. organism: 420 patients with moderate-to-severe chronic heart failure tissue_or_cell_type: Short-term function and two-year clinical events experimental_model: Q-SYMBIO randomized double-blind multicenter trial limitations: One adjunctive-treatment trial; recruitment preceded current heart-failure regimens. Does not show universal benefit or replacement of standard treatment. exposure: 100 mg CoQ10 three times daily added to standard therapy evidence_span: {"source_cache": "artifacts/coq10-research/25282031.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "20ff9f86de1fab16a33ecadfb2c4e09e9017860f01854cfecf490d473fb8fb65", "start_char": 0, "end_char": 2024, "text_sha256": "20ff9f86de1fab16a33ecadfb2c4e09e9017860f01854cfecf490d473fb8fb65"} [coq10-p25282031] The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. (2014). https://pubmed.ncbi.nlm.nih.gov/25282031/ DOI: 10.1016/j.jchf.2014.06.008
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.