Component
Human histidine decarboxylase / HDC
Human histidine decarboxylase / HDC
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The human HDC inhibitor complex resolved a PLP-histidine-methyl-ester external aldimine in its active site.
Experimental context and source evidence
- experimental_model
- Recombinant engineered human HDC; crystallography and enzyme assays
- exposure
- Histidine methyl ester co-crystallization.
- limitations
- Inhibitor-bound engineered protein; not direct observation of every physiological catalytic intermediate.
- nutrient_topic
- Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B6
- organism
- Homo sapiens
- plain_language
- The structure shows how HDC holds a B6-bound substrate mimic.
- primary_references
- [komori-2012-hdc] Structural Study Reveals That Ser-354 Determines Substrate Specificity on Human Histidine Decarboxylase (2012). https://pmc.ncbi.nlm.nih.gov/articles/PMC3436558/ DOI: 10.1074/jbc.M112.381897
- tissue_or_cell_type
- Purified recombinant protein; no intact tissue
Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1059–1069
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Recombinant engineered human HDC; crystallography and enzyme assays · source_derived_draft · unverified_draft
### b6-neuro-hdc-external-aldimine The human HDC inhibitor complex resolved a PLP-histidine-methyl-ester external aldimine in its active site. Condition category: normal nutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The structure shows how HDC holds a B6-bound substrate mimic. organism: Homo sapiens tissue_or_cell_type: Purified recombinant protein; no intact tissue experimental_model: Recombinant engineered human HDC; crystallography and enzyme assays limitations: Inhibitor-bound engineered protein; not direct observation of every physiological catalytic intermediate. exposure: Histidine methyl ester co-crystallization. [komori-2012-hdc] Structural Study Reveals That Ser-354 Determines Substrate Specificity on Human Histidine Decarboxylase (2012). https://pmc.ncbi.nlm.nih.gov/articles/PMC3436558/ DOI: 10.1074/jbc.M112.381897
Complete structured claim and evidenceRecombinant human HDC catalyzes PLP-dependent histidine decarboxylation to histamine.
Experimental context and source evidence
- experimental_model
- Recombinant engineered human HDC; crystallography and enzyme assays
- exposure
- Recombinant HDC enzyme-activity assays.
- limitations
- Engineered soluble HDC construct; histamine release and allergy outcomes were not tested.
- nutrient_topic
- Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B6
- organism
- Homo sapiens
- plain_language
- Activated B6 supports histamine synthesis.
- primary_references
- [komori-2012-hdc] Structural Study Reveals That Ser-354 Determines Substrate Specificity on Human Histidine Decarboxylase (2012). https://pmc.ncbi.nlm.nih.gov/articles/PMC3436558/ DOI: 10.1074/jbc.M112.381897
- tissue_or_cell_type
- Purified recombinant protein; no intact tissue
Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1047–1057
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Recombinant engineered human HDC; crystallography and enzyme assays · source_derived_draft · unverified_draft
### b6-neuro-hdc-histamine Recombinant human HDC catalyzes PLP-dependent histidine decarboxylation to histamine. Condition category: normal nutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Activated B6 supports histamine synthesis. organism: Homo sapiens tissue_or_cell_type: Purified recombinant protein; no intact tissue experimental_model: Recombinant engineered human HDC; crystallography and enzyme assays limitations: Engineered soluble HDC construct; histamine release and allergy outcomes were not tested. exposure: Recombinant HDC enzyme-activity assays. [komori-2012-hdc] Structural Study Reveals That Ser-354 Determines Substrate Specificity on Human Histidine Decarboxylase (2012). https://pmc.ncbi.nlm.nih.gov/articles/PMC3436558/ DOI: 10.1074/jbc.M112.381897
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.