Component
Chinese hamster mitochondrial serine hydroxymethyltransferase / Shmt2
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Shmt2-mutant Chinese hamster ovary cells showed reduced mitochondrial tRNA taurine modification compared with wild type.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary full text, Figure 1F
- experimental_model
- CHO mutant-cell mass spectrometry.
- limitations
- This species-specific machinery defect is not a B6 or folate deprivation experiment.
- nutrient_topic
- Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Taurine
- plain_language
- One-carbon supply can affect the same RNA mark even when the taurine molecule is present.
- primary_references
- Metabolic and chemical regulation of tRNA modification associated with taurine deficiency and human disease. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29390138/ · DOI 10.1093/nar/gky068
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19) · lines 217–223
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · CHO mutant-cell mass spectrometry. · source_derived_draft · unverified_draft
## taurine-shmt2-mutation One-carbon supply can affect the same RNA mark even when the taurine molecule is present. Shmt2-mutant Chinese hamster ovary cells showed reduced mitochondrial tRNA taurine modification compared with wild type. Model: CHO mutant-cell mass spectrometry. Limitations: This species-specific machinery defect is not a B6 or folate deprivation experiment. Evidence access: Primary full text, Figure 1F Metabolic and chemical regulation of tRNA modification associated with taurine deficiency and human disease. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29390138/ · DOI 10.1093/nar/gky068
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.