Component
Hairless nuclear receptor corepressor
Study-defined Hairless nuclear receptor corepressor. Read each linked record for species, exposure and endpoint.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Hairless bound VDR and supported transcriptional repression; the tested ligand-binding and AF2 mutations did not abolish those interactions.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- Keratinocyte-targeted mutant VDR transgenes in VDR-null mice; binding/repression assays
- exposure
- VDR-Hairless interaction/repression assays accompanying transgenic studies.
- limitations
- Engineered mouse VDR system; does not establish a vitamin D supplement as treatment for human hair loss.
- nutrient_topic
- Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin D2 and D3
- organism
- Mouse-model-associated molecular assays
- plain_language
- The receptor also interacts with a gene-silencing partner, independently of normal hormone binding.
- primary_references
- [skorija2005] Ligand-independent actions of the vitamin D receptor maintain hair follicle homeostasis. (2005). https://pubmed.ncbi.nlm.nih.gov/15591533/ DOI: 10.1210/me.2004-0415
- tissue_or_cell_type
- Experimental receptor/corepressor system
Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1210–1221
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Keratinocyte-targeted mutant VDR transgenes in VDR-null mice; binding/repression assays · source_derived_draft · unverified_draft
### vd-hairless-vdr Hairless bound VDR and supported transcriptional repression; the tested ligand-binding and AF2 mutations did not abolish those interactions. Condition category: normal nutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The receptor also interacts with a gene-silencing partner, independently of normal hormone binding. organism: Mouse-model-associated molecular assays tissue_or_cell_type: Experimental receptor/corepressor system experimental_model: Keratinocyte-targeted mutant VDR transgenes in VDR-null mice; binding/repression assays limitations: Engineered mouse VDR system; does not establish a vitamin D supplement as treatment for human hair loss. exposure: VDR-Hairless interaction/repression assays accompanying transgenic studies. cross_nutrient: false [skorija2005] Ligand-independent actions of the vitamin D receptor maintain hair follicle homeostasis. (2005). https://pubmed.ncbi.nlm.nih.gov/15591533/ DOI: 10.1210/me.2004-0415
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.