{"id":"24238310-3adf-57d2-86a1-867eaf377840","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-hairless-vdr","predicate":"binds","statement":"Hairless bound VDR and supported transcriptional repression; the tested ligand-binding and AF2 mutations did not abolish those interactions.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a2f143d7-5bde-5d7c-b0d3-a79b0d235238","mechanism_event_label":"The receptor also interacts with a gene-silencing partner, independently of normal hormone binding.","subject":{"id":"ae9b5065-b2b5-5502-b670-d46100e38a19","slug":"hairless-protein","display_name":"Hairless nuclear receptor corepressor","entity_type_key":"protein"},"object":{"id":"d725020b-bacc-5e90-b370-cda246025c91","slug":"vdr","display_name":"Vitamin D receptor / VDR","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"a2f143d7-5bde-5d7c-b0d3-a79b0d235238","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-hairless-vdr-event","event_type":"biochemical_relationship","label":"The receptor also interacts with a gene-silencing partner, independently of normal hormone binding.","description":"Hairless bound VDR and supported transcriptional repression; the tested ligand-binding and AF2 mutations did not abolish those interactions.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ae9b5065-b2b5-5502-b670-d46100e38a19","slug":"hairless-protein","display_name":"Hairless nuclear receptor corepressor","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d725020b-bacc-5e90-b370-cda246025c91","slug":"vdr","display_name":"Vitamin D receptor / VDR","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Keratinocyte-targeted mutant VDR transgenes in VDR-null mice; binding/repression assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"VDR-Hairless interaction/repression assays accompanying transgenic studies.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Engineered mouse VDR system; does not establish a vitamin D supplement as treatment for human hair loss.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-d","display_name":"Vitamin D2 and D3","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Mouse-model-associated molecular assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The receptor also interacts with a gene-silencing partner, independently of normal hormone binding.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[skorija2005] Ligand-independent actions of the vitamin D receptor maintain hair follicle homeostasis. (2005). https://pubmed.ncbi.nlm.nih.gov/15591533/ DOI: 10.1210/me.2004-0415","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Experimental receptor/corepressor system","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d85b29d7-6974-5452-b07c-7a0ba4c2bb8f","evidence_kind":"source_excerpt","locator":"Lines 1210-1221","start_line":1210,"end_line":1221,"excerpt":"### vd-hairless-vdr\nHairless bound VDR and supported transcriptional repression; the tested ligand-binding and AF2 mutations did not abolish those interactions.\nCondition category: normal\nnutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The receptor also interacts with a gene-silencing partner, independently of normal hormone binding.\norganism: Mouse-model-associated molecular assays\ntissue_or_cell_type: Experimental receptor/corepressor system\nexperimental_model: Keratinocyte-targeted mutant VDR transgenes in VDR-null mice; binding/repression assays\nlimitations: Engineered mouse VDR system; does not establish a vitamin D supplement as treatment for human hair loss.\nexposure: VDR-Hairless interaction/repression assays accompanying transgenic studies.\ncross_nutrient: false\n[skorija2005] Ligand-independent actions of the vitamin D receptor maintain hair follicle homeostasis. (2005). https://pubmed.ncbi.nlm.nih.gov/15591533/ DOI: 10.1210/me.2004-0415","model_system":"Keratinocyte-targeted mutant VDR transgenes in VDR-null mice; binding/repression assays","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [skorija2005] Ligand-independent actions of the vitamin D receptor maintain hair follicle homeostasis. (2005). https://pubmed.ncbi.nlm.nih.gov/15591533/ DOI: 10.1210/me.2004-0415","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c95c763c-5b31-5b3f-a2f8-2dfe5ef0d3ca","stable_key":"import-1deb434a-3547-51a0-a038-87b1ce79ec38","title":"Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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