Component
Glycine-to-serine flux
Independently recorded entity or measured process. Linked claims specify compartment, assay and experimental scope.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
SHMT-mediated glycine-to-serine conversion increased 182 to 205 micromol/kg/hour during restriction, accompanied by higher plasma glycine.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- B6 and folate participate in a reversible reaction; flux direction matters.
- experimental_model
- Thirteen healthy adults (seven men, six women; ages 20–39); glycine and leucine stable-isotope infusion.
- exposure
- Moderate dietary B6 restriction; plasma PLP55±4 to 23±1 nmol/L.
- limitations
- Do not substitute the reverse serine-to-glycine direction or identify the responsible SHMT compartment from whole-body data.
- nutrient_topic
- Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B6
- organism
- Homo sapiens
- plain_language
- The measured direction ran faster, rather than shutting down.
- primary_references
- [b6-lamers2009] Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women (2009). https://pubmed.ncbi.nlm.nih.gov/19158217/ DOI: 10.3945/jn.108.099184
- tissue_or_cell_type
- Human blood and whole-body measurements
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1410–1421
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Thirteen healthy adults (seven men, six women; ages 20–39); glycine and leucine stable-isotope infusion. · source_derived_draft · unverified_draft
### b6-glycine-serine-flux-increase SHMT-mediated glycine-to-serine conversion increased 182 to 205 micromol/kg/hour during restriction, accompanied by higher plasma glycine. Condition category: nutrient_deficiency nutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The measured direction ran faster, rather than shutting down. organism: Homo sapiens tissue_or_cell_type: Human blood and whole-body measurements experimental_model: Thirteen healthy adults (seven men, six women; ages 20–39); glycine and leucine stable-isotope infusion. limitations: Do not substitute the reverse serine-to-glycine direction or identify the responsible SHMT compartment from whole-body data. exposure: Moderate dietary B6 restriction; plasma PLP55±4 to 23±1 nmol/L. cross_nutrient: B6 and folate participate in a reversible reaction; flux direction matters. [b6-lamers2009] Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women (2009). https://pubmed.ncbi.nlm.nih.gov/19158217/ DOI: 10.3945/jn.108.099184
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.