{"id":"6d7ad5e2-9070-584a-acc4-97460bb0c80b","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-glycine-serine-flux-increase","predicate":"restriction_increased_glycine_to_serine_conversion","statement":"SHMT-mediated glycine-to-serine conversion increased 182 to 205 micromol/kg/hour during restriction, accompanied by higher plasma glycine.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"c88fb298-6bd8-5c6e-b5e5-a6bf22e829db","mechanism_event_label":"The measured direction ran faster, rather than shutting down.","subject":{"id":"c0beb226-8842-501f-a147-cac0d9fa7060","slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"},"object":{"id":"74f156f9-0f44-5eb5-b3cd-5275c1f5d7b2","slug":"glycine-to-serine-flux","display_name":"Glycine-to-serine flux","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c88fb298-6bd8-5c6e-b5e5-a6bf22e829db","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-glycine-serine-flux-increase-event","event_type":"observed_intervention","label":"The measured direction ran faster, rather than shutting down.","description":"SHMT-mediated glycine-to-serine conversion increased 182 to 205 micromol/kg/hour during restriction, accompanied by higher plasma glycine.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2b507258-430c-51fe-9fd2-e510c2c197a9","slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"},"role":"substrate","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c882cd0b-9d83-5b07-bd1c-fe4d45657dcb","slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"},"role":"product","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c0beb226-8842-501f-a147-cac0d9fa7060","slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"74f156f9-0f44-5eb5-b3cd-5275c1f5d7b2","slug":"glycine-to-serine-flux","display_name":"Glycine-to-serine flux","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"B6 and folate participate in a reversible reaction; flux direction matters.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Thirteen healthy adults (seven men, six women; ages 20–39); glycine and leucine stable-isotope infusion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Moderate dietary B6 restriction; plasma PLP55±4 to 23±1 nmol/L.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Do not substitute the reverse serine-to-glycine direction or identify the responsible SHMT compartment from whole-body data.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The measured direction ran faster, rather than shutting down.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b6-lamers2009] Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women (2009). https://pubmed.ncbi.nlm.nih.gov/19158217/ DOI: 10.3945/jn.108.099184","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human blood and whole-body measurements","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"24b54c62-33c6-5dc6-941f-6dfd0cbd80be","evidence_kind":"source_excerpt","locator":"Lines 1410-1421","start_line":1410,"end_line":1421,"excerpt":"### b6-glycine-serine-flux-increase\nSHMT-mediated glycine-to-serine conversion increased 182 to 205 micromol/kg/hour during restriction, accompanied by higher plasma glycine.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The measured direction ran faster, rather than shutting down.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood and whole-body measurements\nexperimental_model: Thirteen healthy adults (seven men, six women; ages 20–39); glycine and leucine stable-isotope infusion.\nlimitations: Do not substitute the reverse serine-to-glycine direction or identify the responsible SHMT compartment from whole-body data.\nexposure: Moderate dietary B6 restriction; plasma PLP55±4 to 23±1 nmol/L.\ncross_nutrient: B6 and folate participate in a reversible reaction; flux direction matters.\n[b6-lamers2009] Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women (2009). https://pubmed.ncbi.nlm.nih.gov/19158217/ DOI: 10.3945/jn.108.099184","model_system":"Thirteen healthy adults (seven men, six women; ages 20–39); glycine and leucine stable-isotope infusion.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b6-lamers2009] Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women (2009). https://pubmed.ncbi.nlm.nih.gov/19158217/ DOI: 10.3945/jn.108.099184","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"251773bb-16f5-5903-b135-db4a61d9dec4","stable_key":"import-1310afbd-6010-586e-805d-551d846da421","title":"Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ef0019b344b2219220f801a84d0d138ff6880c1be1a59540d9034bfa4334f61e","revision_id":"cac3555f-48af-5c52-a84e-add4482c87fb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}