Component
Glutamate release from excitatory terminals
Glutamate release from excitatory terminals. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Endogenous cannabinoids retrogradely inhibited presynaptic calcium influx at excitatory synapses onto Purkinje cells.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/thc-research/11301030.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c696bee2c487e7deca703c5c903b38935f6d635f29bbf4ebf498869eaa4491c0", "start_char": 0, "end_char": 1025, "text_sha256": "c696bee2c487e7deca703c5c903b38935f6d635f29bbf4ebf498869eaa4491c0"}
- experimental_model
- Presynaptic calcium imaging at excitatory synapses onto cerebellar Purkinje cells
- exposure
- Depolarisation-induced suppression of excitation with calcium measurement
- limitations
- Extends the mechanism to excitatory synapses in a different brain region and measures the calcium step directly.
- nutrient_topic
- THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
- organism
- Rodent
- plain_language
- The same backwards signal works on excitatory terminals too, by closing the same calcium gate.
- primary_references
- [thc-p11301030] Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells. (2001). https://pubmed.ncbi.nlm.nih.gov/11301030/ DOI: 10.1016/s0896-6273(01)00246-x
- tissue_or_cell_type
- Cerebellum
THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 296–307
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Presynaptic calcium imaging at excitatory synapses onto cerebellar Purkinje cells · source_derived_draft · unverified_draft
### thc-retrograde-purkinje Endogenous cannabinoids retrogradely inhibited presynaptic calcium influx at excitatory synapses onto Purkinje cells. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: The same backwards signal works on excitatory terminals too, by closing the same calcium gate. organism: Rodent tissue_or_cell_type: Cerebellum experimental_model: Presynaptic calcium imaging at excitatory synapses onto cerebellar Purkinje cells limitations: Extends the mechanism to excitatory synapses in a different brain region and measures the calcium step directly. exposure: Depolarisation-induced suppression of excitation with calcium measurement evidence_span: {"source_cache": "artifacts/thc-research/11301030.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c696bee2c487e7deca703c5c903b38935f6d635f29bbf4ebf498869eaa4491c0", "start_char": 0, "end_char": 1025, "text_sha256": "c696bee2c487e7deca703c5c903b38935f6d635f29bbf4ebf498869eaa4491c0"} [thc-p11301030] Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells. (2001). https://pubmed.ncbi.nlm.nih.gov/11301030/ DOI: 10.1016/s0896-6273(01)00246-x
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.