Component
The hydrophobic alcohol pocket of the GIRK channel cytoplasmic domain
The hydrophobic alcohol pocket of the GIRK channel cytoplasmic domain. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
A discrete alcohol pocket in the channel cytoplasmic domain was shown to be involved in GIRK channel activation.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/alcohol-research/19561601.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6aa4c10bd615439d1b5e008da1031a4ed244aeef6a0be4764930a7f183778428", "start_char": 0, "end_char": 1103, "text_sha256": "6aa4c10bd615439d1b5e008da1031a4ed244aeef6a0be4764930a7f183778428"}
- experimental_model
- Mutagenesis and structural mapping of the GIRK cytoplasmic domain
- exposure
- Alcohol binding to a defined hydrophobic pocket
- limitations
- Locates the site to a discrete pocket, which supports direct binding over a bulk membrane effect.
- nutrient_topic
- Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. · Ethanol
- organism
- Recombinant channels
- plain_language
- The same picture again: a specific pocket, not a general softening of the membrane.
- primary_references
- [alcohol-p19561601] A discrete alcohol pocket involved in GIRK channel activation. (2009). https://pubmed.ncbi.nlm.nih.gov/19561601/ DOI: 10.1038/nn.2358
- tissue_or_cell_type
- GIRK cytoplasmic domain
Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21) · lines 397–408
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mutagenesis and structural mapping of the GIRK cytoplasmic domain · source_derived_draft · unverified_draft
### alcohol-girk-pocket A discrete alcohol pocket in the channel cytoplasmic domain was shown to be involved in GIRK channel activation. Condition category: normal nutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. plain_language: The same picture again: a specific pocket, not a general softening of the membrane. organism: Recombinant channels tissue_or_cell_type: GIRK cytoplasmic domain experimental_model: Mutagenesis and structural mapping of the GIRK cytoplasmic domain limitations: Locates the site to a discrete pocket, which supports direct binding over a bulk membrane effect. exposure: Alcohol binding to a defined hydrophobic pocket evidence_span: {"source_cache": "artifacts/alcohol-research/19561601.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6aa4c10bd615439d1b5e008da1031a4ed244aeef6a0be4764930a7f183778428", "start_char": 0, "end_char": 1103, "text_sha256": "6aa4c10bd615439d1b5e008da1031a4ed244aeef6a0be4764930a7f183778428"} [alcohol-p19561601] A discrete alcohol pocket involved in GIRK channel activation. (2009). https://pubmed.ncbi.nlm.nih.gov/19561601/ DOI: 10.1038/nn.2358
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.