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(2009). https://pubmed.ncbi.nlm.nih.gov/19561601/ DOI: 10.1038/nn.2358","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"GIRK cytoplasmic domain","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"71f13711-9004-5111-927c-2f1fe84257bf","evidence_kind":"source_excerpt","locator":"Lines 397-408","start_line":397,"end_line":408,"excerpt":"### alcohol-girk-pocket\nA discrete alcohol pocket in the channel cytoplasmic domain was shown to be involved in GIRK channel activation.\nCondition category: normal\nnutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes.\nplain_language: The same picture again: a specific pocket, not a general softening of the membrane.\norganism: Recombinant channels\ntissue_or_cell_type: GIRK cytoplasmic domain\nexperimental_model: Mutagenesis and structural mapping of the GIRK cytoplasmic domain\nlimitations: Locates the site to a discrete pocket, which supports direct binding over a bulk membrane effect.\nexposure: Alcohol binding to a defined hydrophobic pocket\nevidence_span: {\"source_cache\": \"artifacts/alcohol-research/19561601.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6aa4c10bd615439d1b5e008da1031a4ed244aeef6a0be4764930a7f183778428\", \"start_char\": 0, \"end_char\": 1103, \"text_sha256\": \"6aa4c10bd615439d1b5e008da1031a4ed244aeef6a0be4764930a7f183778428\"}\n[alcohol-p19561601] A discrete alcohol pocket involved in GIRK channel activation. 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