Component

Aged garlic extract plus steam-distilled oil in the Shandong trial

Aged garlic extract plus steam-distilled oil in the Shandong trial. Interpret through the linked study species, preparation, exposure and measured endpoint.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Garlic supplementation did not significantly change cardiovascular mortality in the long-term Shandong analysis.

    Aged garlic extract plus steam-distilled oil in the Shandong trial → Cardiovascular mortality in the Shandong trial source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text available; selected claim-relevant methods, results, tables/figures and limitations reviewed. Supplemental proteome and all secondary findings are not exhaustively extracted.
    experimental_contrast
    {"intervention": "Assigned aged garlic extract plus distilled oil regimen", "comparator": "Assigned garlic placebo, separately randomized other interventions", "endpoint": "Garlic supplementation did not significantly change cardiovascular mortality in the long-term Shandong analysis.", "effect_direction": "no_detected_change", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    3365 participants in factorial trial; extract plus oil for 7.3 years, 22.3-year follow-up.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    High-risk population, long-term endpoint-specific inference; mortality boundary is sensitive to rounding. Vitamins C/E/selenium were a separate intervention, not demonstrated synergy or allicin cancer therapy.
    plain_language
    Garlic supplementation did not significantly change cardiovascular mortality in the long-term Shandong analysis.
    primary_references
    Effects of <i>Helicobacter pylori</i> treatment and vitamin and garlic supplementation on gastric cancer incidence and mortality: follow-up of a randomized intervention trial. | 2019 | DOI 10.1136/bmj.l5016 | PMID 31511230 | https://pubmed.ncbi.nlm.nih.gov/31511230/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC6737461/ | https://doi.org/10.1136/bmj.l5016
    source_locator
    Reviewed reference lines 97-97; exact primary location described in quoted passage where extracted.

    Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 97–97

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · 3365 participants in factorial trial; extract plus oil for 7.3 years, 22.3-year follow-up. · source_derived_draft · unverified_draft

    **Shandong outcomes and formulation.** The factorial trial included 3,365 residents of a high-risk Chinese region. The garlic regimen was two capsules, each containing 200 mg aged garlic extract and 1 mg steam-distilled garlic oil, twice daily for 7.3 years. Over 22.3 years, gastric-cancer incidence was not significantly reduced (adjusted odds ratio 0.81, 95% CI 0.57–1.13), while gastric-cancer mortality was lower (hazard ratio 0.66, 95% CI 0.43–1.00 after rounding). The secondary analysis reports the upper bound as 0.999. Other cancer and cardiovascular-mortality results were not significant. This endpoint-specific, borderline mortality signal must not be replaced with either a blanket null or a cancer-treatment claim. The independently assigned vitamin intervention contained C, E, and selenium; its effects are not garlic effects or proof of garlic–vitamin synergy. [Li 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6737461/) [Guo 2020](https://pmc.ncbi.nlm.nih.gov/articles/PMC7320300/)
    Complete structured claim and evidence

  2. Garlic supplementation did not significantly reduce gastric cancer incidence: adjusted OR 0.81, 95% CI 0.57-1.13.

    Aged garlic extract plus steam-distilled oil in the Shandong trial → Gastric cancer incidence in the Shandong trial source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text available; selected claim-relevant methods, results, tables/figures and limitations reviewed. Supplemental proteome and all secondary findings are not exhaustively extracted.
    experimental_contrast
    {"intervention": "Assigned aged garlic extract plus distilled oil regimen", "comparator": "Assigned garlic placebo, separately randomized other interventions", "endpoint": "Garlic supplementation did not significantly reduce gastric cancer incidence: adjusted OR 0.81, 95% CI 0.57-1.13.", "effect_direction": "no_detected_change", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    3365 participants in factorial trial; extract plus oil for 7.3 years, 22.3-year follow-up.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    High-risk population, long-term endpoint-specific inference; mortality boundary is sensitive to rounding. Vitamins C/E/selenium were a separate intervention, not demonstrated synergy or allicin cancer therapy.
    plain_language
    Garlic supplementation did not significantly reduce gastric cancer incidence: adjusted OR 0.81, 95% CI 0.57-1.13.
    primary_references
    Effects of <i>Helicobacter pylori</i> treatment and vitamin and garlic supplementation on gastric cancer incidence and mortality: follow-up of a randomized intervention trial. | 2019 | DOI 10.1136/bmj.l5016 | PMID 31511230 | https://pubmed.ncbi.nlm.nih.gov/31511230/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC6737461/ | https://doi.org/10.1136/bmj.l5016
    source_locator
    Reviewed reference lines 97-97; exact primary location described in quoted passage where extracted.

    Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 97–97

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · 3365 participants in factorial trial; extract plus oil for 7.3 years, 22.3-year follow-up. · source_derived_draft · unverified_draft

    **Shandong outcomes and formulation.** The factorial trial included 3,365 residents of a high-risk Chinese region. The garlic regimen was two capsules, each containing 200 mg aged garlic extract and 1 mg steam-distilled garlic oil, twice daily for 7.3 years. Over 22.3 years, gastric-cancer incidence was not significantly reduced (adjusted odds ratio 0.81, 95% CI 0.57–1.13), while gastric-cancer mortality was lower (hazard ratio 0.66, 95% CI 0.43–1.00 after rounding). The secondary analysis reports the upper bound as 0.999. Other cancer and cardiovascular-mortality results were not significant. This endpoint-specific, borderline mortality signal must not be replaced with either a blanket null or a cancer-treatment claim. The independently assigned vitamin intervention contained C, E, and selenium; its effects are not garlic effects or proof of garlic–vitamin synergy. [Li 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6737461/) [Guo 2020](https://pmc.ncbi.nlm.nih.gov/articles/PMC7320300/)
    Complete structured claim and evidence

  3. Garlic supplementation was associated with lower gastric cancer mortality: HR 0.66, 95% CI 0.43-1.00 rounded; secondary analysis reports 0.999.

    Aged garlic extract plus steam-distilled oil in the Shandong trial → Gastric cancer mortality in the Shandong trial source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text available; selected claim-relevant methods, results, tables/figures and limitations reviewed. Supplemental proteome and all secondary findings are not exhaustively extracted.
    experimental_contrast
    {"intervention": "Assigned aged garlic extract plus distilled oil regimen", "comparator": "Assigned garlic placebo, separately randomized other interventions", "endpoint": "Garlic supplementation was associated with lower gastric cancer mortality: HR 0.66, 95% CI 0.43-1.00 rounded; secondary analysis reports 0.999.", "effect_direction": "decrease", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    3365 participants in factorial trial; extract plus oil for 7.3 years, 22.3-year follow-up.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    High-risk population, long-term endpoint-specific inference; mortality boundary is sensitive to rounding. Vitamins C/E/selenium were a separate intervention, not demonstrated synergy or allicin cancer therapy.
    plain_language
    Garlic supplementation was associated with lower gastric cancer mortality: HR 0.66, 95% CI 0.43-1.00 rounded; secondary analysis reports 0.999.
    primary_references
    Effects of <i>Helicobacter pylori</i> treatment and vitamin and garlic supplementation on gastric cancer incidence and mortality: follow-up of a randomized intervention trial. | 2019 | DOI 10.1136/bmj.l5016 | PMID 31511230 | https://pubmed.ncbi.nlm.nih.gov/31511230/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC6737461/ | https://doi.org/10.1136/bmj.l5016
    source_locator
    Reviewed reference lines 97-97; exact primary location described in quoted passage where extracted.

    Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 97–97

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · 3365 participants in factorial trial; extract plus oil for 7.3 years, 22.3-year follow-up. · source_derived_draft · unverified_draft

    **Shandong outcomes and formulation.** The factorial trial included 3,365 residents of a high-risk Chinese region. The garlic regimen was two capsules, each containing 200 mg aged garlic extract and 1 mg steam-distilled garlic oil, twice daily for 7.3 years. Over 22.3 years, gastric-cancer incidence was not significantly reduced (adjusted odds ratio 0.81, 95% CI 0.57–1.13), while gastric-cancer mortality was lower (hazard ratio 0.66, 95% CI 0.43–1.00 after rounding). The secondary analysis reports the upper bound as 0.999. Other cancer and cardiovascular-mortality results were not significant. This endpoint-specific, borderline mortality signal must not be replaced with either a blanket null or a cancer-treatment claim. The independently assigned vitamin intervention contained C, E, and selenium; its effects are not garlic effects or proof of garlic–vitamin synergy. [Li 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6737461/) [Guo 2020](https://pmc.ncbi.nlm.nih.gov/articles/PMC7320300/)
    Complete structured claim and evidence

What acts on it

  1. The garlic-extract-oil-shandong study is a preparation-specific translation comparison; its outcomes are not assigned to purified allicin.

    Allicin → Aged garlic extract plus steam-distilled oil in the Shandong trial source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text available; selected claim-relevant methods, results, tables/figures and limitations reviewed. Supplemental proteome and all secondary findings are not exhaustively extracted.
    experimental_model
    Editorial study-scope relationship, not experimental causation or chemical composition.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Unsigned navigation only. Does not assert allicin content, metabolic conversion, causation or intervention equivalence.
    plain_language
    The garlic-extract-oil-shandong study is a preparation-specific translation comparison; its outcomes are not assigned to purified allicin.
    primary_references
    Effects of <i>Helicobacter pylori</i> treatment and vitamin and garlic supplementation on gastric cancer incidence and mortality: follow-up of a randomized intervention trial. | 2019 | DOI 10.1136/bmj.l5016 | PMID 31511230 | https://pubmed.ncbi.nlm.nih.gov/31511230/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC6737461/ | https://doi.org/10.1136/bmj.l5016
    source_locator
    Reviewed reference lines 97-97; exact primary location described in quoted passage where extracted.

    Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 97–97

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Editorial study-scope relationship, not experimental causation or chemical composition. · source_derived_draft · unverified_draft

    **Shandong outcomes and formulation.** The factorial trial included 3,365 residents of a high-risk Chinese region. The garlic regimen was two capsules, each containing 200 mg aged garlic extract and 1 mg steam-distilled garlic oil, twice daily for 7.3 years. Over 22.3 years, gastric-cancer incidence was not significantly reduced (adjusted odds ratio 0.81, 95% CI 0.57–1.13), while gastric-cancer mortality was lower (hazard ratio 0.66, 95% CI 0.43–1.00 after rounding). The secondary analysis reports the upper bound as 0.999. Other cancer and cardiovascular-mortality results were not significant. This endpoint-specific, borderline mortality signal must not be replaced with either a blanket null or a cancer-treatment claim. The independently assigned vitamin intervention contained C, E, and selenium; its effects are not garlic effects or proof of garlic–vitamin synergy. [Li 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6737461/) [Guo 2020](https://pmc.ncbi.nlm.nih.gov/articles/PMC7320300/)
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.