{"id":"72ef137a-53ca-561b-9dc7-5fa55aa3a295","stable_key":"c836a883-ac18-5eb2-9971-2f0b542feba8:scope-garlic-extract-oil-shandong","predicate":"has_distinct_clinical_preparation_comparison","statement":"The garlic-extract-oil-shandong study is a preparation-specific translation comparison; its outcomes are not assigned to purified allicin. ","claim_class":"identity","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"bbe74bce-ac77-5229-8093-b561214e7c60","mechanism_event_label":"The garlic-extract-oil-shandong study is a preparation-specific translation comparison; its outcomes are not assigned to purified allicin. ","subject":{"id":"85c86fcf-3060-5fae-b567-4f089990ab2d","slug":"allicin","display_name":"Allicin","entity_type_key":"small_molecule"},"object":{"id":"0b211f33-addf-5991-8304-2234221216a8","slug":"garlic-extract-oil-shandong","display_name":"Aged garlic extract plus steam-distilled oil in the Shandong trial","entity_type_key":"botanical"},"evidence_count":1,"mechanism_event":{"id":"bbe74bce-ac77-5229-8093-b561214e7c60","stable_key":"c836a883-ac18-5eb2-9971-2f0b542feba8:scope-garlic-extract-oil-shandong-event","event_type":"experimental_scope_comparison","label":"The garlic-extract-oil-shandong study is a preparation-specific translation comparison; its outcomes are not assigned to purified allicin. ","description":"**Shandong outcomes and formulation.** The factorial trial included 3,365 residents of a high-risk Chinese region. The garlic regimen was two capsules, each containing 200 mg aged garlic extract and 1 mg steam-distilled garlic oil, twice daily for 7.3 years. Over 22.3 years, gastric-cancer incidence was not significantly reduced (adjusted odds ratio 0.81, 95% CI 0.57–1.13), while gastric-cancer mortality was lower (hazard ratio 0.66, 95% CI 0.43–1.00 after rounding). The secondary analysis reports the upper bound as 0.999. Other cancer and cardiovascular-mortality results were not significant. This endpoint-specific, borderline mortality signal must not be replaced with either a blanket null or a cancer-treatment claim. The independently assigned vitamin intervention contained C, E, and selenium; its effects are not garlic effects or proof of garlic–vitamin synergy. [Li 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6737461/) [Guo 2020](https://pmc.ncbi.nlm.nih.gov/articles/PMC7320300/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"85c86fcf-3060-5fae-b567-4f089990ab2d","slug":"allicin","display_name":"Allicin","entity_type_key":"small_molecule"},"role":"tested factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"0b211f33-addf-5991-8304-2234221216a8","slug":"garlic-extract-oil-shandong","display_name":"Aged garlic extract plus steam-distilled oil in the Shandong trial","entity_type_key":"botanical"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text available; selected claim-relevant methods, results, tables/figures and limitations reviewed. Supplemental proteome and all secondary findings are not exhaustively extracted.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Editorial study-scope relationship, not experimental causation or chemical composition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Unsigned navigation only. Does not assert allicin content, metabolic conversion, causation or intervention equivalence.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The garlic-extract-oil-shandong study is a preparation-specific translation comparison; its outcomes are not assigned to purified allicin. ","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effects of <i>Helicobacter pylori</i> treatment and vitamin and garlic supplementation on gastric cancer incidence and mortality: follow-up of a randomized intervention trial. | 2019 | DOI 10.1136/bmj.l5016 | PMID 31511230 | https://pubmed.ncbi.nlm.nih.gov/31511230/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC6737461/ | https://doi.org/10.1136/bmj.l5016","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 97-97; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"69aac2cd-0d01-57ad-b050-923b0fbe070c","evidence_kind":"source_excerpt","locator":"Lines 97-97","start_line":97,"end_line":97,"excerpt":"**Shandong outcomes and formulation.** The factorial trial included 3,365 residents of a high-risk Chinese region. The garlic regimen was two capsules, each containing 200 mg aged garlic extract and 1 mg steam-distilled garlic oil, twice daily for 7.3 years. Over 22.3 years, gastric-cancer incidence was not significantly reduced (adjusted odds ratio 0.81, 95% CI 0.57–1.13), while gastric-cancer mortality was lower (hazard ratio 0.66, 95% CI 0.43–1.00 after rounding). The secondary analysis reports the upper bound as 0.999. Other cancer and cardiovascular-mortality results were not significant. This endpoint-specific, borderline mortality signal must not be replaced with either a blanket null or a cancer-treatment claim. The independently assigned vitamin intervention contained C, E, and selenium; its effects are not garlic effects or proof of garlic–vitamin synergy. [Li 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6737461/) [Guo 2020](https://pmc.ncbi.nlm.nih.gov/articles/PMC7320300/)","model_system":"Editorial study-scope relationship, not experimental causation or chemical composition.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"10820a6b-594a-547d-97f9-906ab4cc1d6e","stable_key":"import-c836a883-ac18-5eb2-9971-2f0b542feba8","title":"Allicin: detailed mechanisms of action (reviewed 5 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication.","file_path":"","sha256":"2475d3eb681100a0a34577a47b7cba5b251df866fbd6ce795122ccabee360018","revision_id":"590df96d-2ed1-5763-b04c-bf0e096e603c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}