Component
Human G0/G1 switch protein 2 / G0S2
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Adipose G0S2 transcript levels decreased after fasting, independent of GH blockade.
Experimental context and source evidence
- evidence_access
- Primary full-text Results: Regulation of lipolysis, DOI 10.1210/jc.2016-3835
- experimental_model
- Same human adipose biopsy study.
- limitations
- Expression alone does not establish which lipase step controlled whole-body flux.
- nutrient_topic
- Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished. · Fasting / abstention from energy intake
- plain_language
- A second fat-release regulator changed.
- primary_references
- Substrate Metabolism and Insulin Sensitivity During Fasting in Obese Human Subjects: Impact of GH Blockade. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28324055/ · DOI 10.1210/jc.2016-3835
Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18) · lines 232–238
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Same human adipose biopsy study. · source_derived_draft · unverified_draft
## fast-adipose-g0s2 A second fat-release regulator changed. Adipose G0S2 transcript levels decreased after fasting, independent of GH blockade. Model: Same human adipose biopsy study. Limitations: Expression alone does not establish which lipase step controlled whole-body flux. Evidence access: Primary full-text Results: Regulation of lipolysis, DOI 10.1210/jc.2016-3835 Substrate Metabolism and Insulin Sensitivity During Fasting in Obese Human Subjects: Impact of GH Blockade. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28324055/ · DOI 10.1210/jc.2016-3835
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.