{"id":"cb60d1ce-ab3f-55ad-a6e6-84da460d9b12","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-adipose-g0s2","predicate":"reduces_transcript","statement":"Adipose G0S2 transcript levels decreased after fasting, independent of GH blockade.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3842b922-b3ed-5462-b986-94faf41db2d4","mechanism_event_label":"A second fat-release regulator changed.","subject":{"id":"2d5df4b9-44d7-56a5-8ecf-7c08c0ae9f4f","slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"},"object":{"id":"0d94cbcc-2629-59da-b562-3abb383bd70b","slug":"g0s2","display_name":"Human G0/G1 switch protein 2 / G0S2","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"3842b922-b3ed-5462-b986-94faf41db2d4","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-adipose-g0s2-event","event_type":"observed_relationship","label":"A second fat-release regulator changed.","description":"Adipose G0S2 transcript levels decreased after fasting, independent of GH blockade.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2d5df4b9-44d7-56a5-8ecf-7c08c0ae9f4f","slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0d94cbcc-2629-59da-b562-3abb383bd70b","slug":"g0s2","display_name":"Human G0/G1 switch protein 2 / G0S2","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full-text Results: Regulation of lipolysis, DOI 10.1210/jc.2016-3835","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same human adipose biopsy study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Expression alone does not establish which lipase step controlled whole-body flux.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"A second fat-release regulator changed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Substrate Metabolism and Insulin Sensitivity During Fasting in Obese Human Subjects: Impact of GH Blockade. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28324055/ · DOI 10.1210/jc.2016-3835","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b80a932b-3ab1-583c-97f3-a290c283f862","evidence_kind":"source_excerpt","locator":"Lines 232-238","start_line":232,"end_line":238,"excerpt":"## fast-adipose-g0s2\nA second fat-release regulator changed.\nAdipose G0S2 transcript levels decreased after fasting, independent of GH blockade.\nModel: Same human adipose biopsy study.\nLimitations: Expression alone does not establish which lipase step controlled whole-body flux.\nEvidence access: Primary full-text Results: Regulation of lipolysis, DOI 10.1210/jc.2016-3835\nSubstrate Metabolism and Insulin Sensitivity During Fasting in Obese Human Subjects: Impact of GH Blockade. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28324055/ · DOI 10.1210/jc.2016-3835","model_system":"Same human adipose biopsy study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"991b7fd94be84c0f1e622e0672eda03d600b388dfd7825e219aa1678d1c7983a","revision_id":"ce85d3f4-4eaf-5aee-bddb-0f0ce7fe2211","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}