Component

Food intake

Food intake. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Appetite suppression and weight loss followed administration of the cannabinoid antagonist SR141716.

    SR141716A / rimonabant, a CB1 receptor antagonist → Food intake source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/thc-research/9718088.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4714909d64a1c671c1c3dcec0496b80cc6a09e0a8d0368ed6b8be8aa284456e2", "start_char": 0, "end_char": 590, "text_sha256": "4714909d64a1c671c1c3dcec0496b80cc6a09e0a8d0368ed6b8be8aa284456e2"}
    experimental_model
    The CB1 antagonist SR141716 given for appetite and body weight measurement
    exposure
    SR141716 administration with food intake and weight measurement
    limitations
    Establishes that blocking the receptor suppresses appetite, which is the mirror of the drug effect. Rimonabant was later withdrawn for psychiatric adverse effects, which is not in this record.
    nutrient_topic
    THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
    organism
    Rodent
    plain_language
    Blocking the receptor takes hunger away, which is why the drug increases it.
    primary_references
    [thc-p9718088] Appetite suppression and weight loss after the cannabinoid antagonist SR 141716. (1998). https://pubmed.ncbi.nlm.nih.gov/9718088/ DOI: 10.1016/s0024-3205(98)00322-1
    tissue_or_cell_type
    Whole body

    THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 491–502

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · The CB1 antagonist SR141716 given for appetite and body weight measurement · source_derived_draft · unverified_draft

    ### thc-antagonist-suppresses-appetite Appetite suppression and weight loss followed administration of the cannabinoid antagonist SR141716. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: Blocking the receptor takes hunger away, which is why the drug increases it. organism: Rodent tissue_or_cell_type: Whole body experimental_model: The CB1 antagonist SR141716 given for appetite and body weight measurement limitations: Establishes that blocking the receptor suppresses appetite, which is the mirror of the drug effect. Rimonabant was later withdrawn for psychiatric adverse effects, which is not in this record. exposure: SR141716 administration with food intake and weight measurement evidence_span: {"source_cache": "artifacts/thc-research/9718088.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4714909d64a1c671c1c3dcec0496b80cc6a09e0a8d0368ed6b8be8aa284456e2", "start_char": 0, "end_char": 590, "text_sha256": "4714909d64a1c671c1c3dcec0496b80cc6a09e0a8d0368ed6b8be8aa284456e2"} [thc-p9718088] Appetite suppression and weight loss after the cannabinoid antagonist SR 141716. (1998). https://pubmed.ncbi.nlm.nih.gov/9718088/ DOI: 10.1016/s0024-3205(98)00322-1
    Complete structured claim and evidence

  2. CB1 cannabinoid receptor activation modulated food intake in mice, with agonists and antagonists moving intake in opposite directions.

    Human cannabinoid receptor 1 / CB1 / CNR1 → Food intake source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/thc-research/15778743.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "813967ae44806749032cc8f98384086ca5ae7f0c4a6367a56cbb375680e205ac", "start_char": 0, "end_char": 1724, "text_sha256": "813967ae44806749032cc8f98384086ca5ae7f0c4a6367a56cbb375680e205ac"}
    experimental_model
    CB1-mediated modulation of food intake measured in mice
    exposure
    Cannabinoid agonists and antagonists on feeding
    limitations
    A bidirectional pharmacological test of the same axis in a second species.
    nutrient_topic
    THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
    organism
    Mouse
    plain_language
    The receptor sets appetite in both directions.
    primary_references
    [thc-p15778743] CB1 cannabinoid receptor-mediated modulation of food intake in mice. (2005). https://pubmed.ncbi.nlm.nih.gov/15778743/ DOI: 10.1038/sj.bjp.0706157
    tissue_or_cell_type
    Whole body

    THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 504–515

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · CB1-mediated modulation of food intake measured in mice · source_derived_draft · unverified_draft

    ### thc-cb1-food-intake CB1 cannabinoid receptor activation modulated food intake in mice, with agonists and antagonists moving intake in opposite directions. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: The receptor sets appetite in both directions. organism: Mouse tissue_or_cell_type: Whole body experimental_model: CB1-mediated modulation of food intake measured in mice limitations: A bidirectional pharmacological test of the same axis in a second species. exposure: Cannabinoid agonists and antagonists on feeding evidence_span: {"source_cache": "artifacts/thc-research/15778743.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "813967ae44806749032cc8f98384086ca5ae7f0c4a6367a56cbb375680e205ac", "start_char": 0, "end_char": 1724, "text_sha256": "813967ae44806749032cc8f98384086ca5ae7f0c4a6367a56cbb375680e205ac"} [thc-p15778743] CB1 cannabinoid receptor-mediated modulation of food intake in mice. (2005). https://pubmed.ncbi.nlm.nih.gov/15778743/ DOI: 10.1038/sj.bjp.0706157
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Rats displayed strong preference for emulsions containing linoleic acid in a two-bottle-choice sham-feeding test, and the preference was blocked by the peripherally restricted CB1 antagonists AM6546 and URB447.

    Jejunal endocannabinoid concentration → Preference for dietary unsaturated fat source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/thc-research/23463697.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cf035f4613f2090d3eaa60f90857a2dd265f69435b63d470e3dbe82f2350a079", "start_char": 0, "end_char": 1315, "text_sha256": "cf035f4613f2090d3eaa60f90857a2dd265f69435b63d470e3dbe82f2350a079"}
    experimental_model
    Sham-feeding protocol in rats with jejunal endocannabinoid measurement and peripheral CB1 antagonists
    exposure
    Sham feeding of defined fatty acid emulsions with peripherally restricted CB1 antagonists
    limitations
    Sham feeding separates oral exposure from absorption, and the peripherally restricted antagonists separate a gut mechanism from a brain one.
    nutrient_topic
    THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
    organism
    Rat
    plain_language
    The gut messenger is what makes the animal want more of that fat, and blocking it outside the brain removes the wanting.
    primary_references
    [thc-p23463697] Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats. (2013). https://pubmed.ncbi.nlm.nih.gov/23463697/ DOI: 10.1096/fj.13-227587
    tissue_or_cell_type
    Jejunum and behaviour

    THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 712–723

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Sham-feeding protocol in rats with jejunal endocannabinoid measurement and peripheral CB1 antagonists · source_derived_draft · unverified_draft

    ### thc-gut-endocannabinoids-drive-preference Rats displayed strong preference for emulsions containing linoleic acid in a two-bottle-choice sham-feeding test, and the preference was blocked by the peripherally restricted CB1 antagonists AM6546 and URB447. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: The gut messenger is what makes the animal want more of that fat, and blocking it outside the brain removes the wanting. organism: Rat tissue_or_cell_type: Jejunum and behaviour experimental_model: Sham-feeding protocol in rats with jejunal endocannabinoid measurement and peripheral CB1 antagonists limitations: Sham feeding separates oral exposure from absorption, and the peripherally restricted antagonists separate a gut mechanism from a brain one. exposure: Sham feeding of defined fatty acid emulsions with peripherally restricted CB1 antagonists evidence_span: {"source_cache": "artifacts/thc-research/23463697.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cf035f4613f2090d3eaa60f90857a2dd265f69435b63d470e3dbe82f2350a079", "start_char": 0, "end_char": 1315, "text_sha256": "cf035f4613f2090d3eaa60f90857a2dd265f69435b63d470e3dbe82f2350a079"} [thc-p23463697] Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats. (2013). https://pubmed.ncbi.nlm.nih.gov/23463697/ DOI: 10.1096/fj.13-227587
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards