{"id":"7f0e5538-9932-5eb4-ba8f-3d49807868ad","stable_key":"05a3cf47-e660-5ab3-8c32-5eba9847cf0a:thc-antagonist-suppresses-appetite","predicate":"reduces","statement":"Appetite suppression and weight loss followed administration of the cannabinoid antagonist SR141716.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"517aabe2-9501-59ec-a031-808743336607","mechanism_event_label":"Blocking the receptor takes hunger away, which is why the drug increases it.","subject":{"id":"f4a1a50c-5e9d-5f48-98e9-d9c808c7b73a","slug":"sr141716a","display_name":"SR141716A / rimonabant, a CB1 receptor antagonist","entity_type_key":"drug"},"object":{"id":"49de215e-5399-5593-9477-5a0e78dbe6be","slug":"food-intake","display_name":"Food intake","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"517aabe2-9501-59ec-a031-808743336607","stable_key":"05a3cf47-e660-5ab3-8c32-5eba9847cf0a:thc-antagonist-suppresses-appetite-event","event_type":"biochemical_relationship","label":"Blocking the receptor takes hunger away, which is why the drug increases it.","description":"Appetite suppression and weight loss followed administration of the cannabinoid antagonist SR141716.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bb913762-c48e-52d9-8ffc-ce59a53e7124","slug":"body-weight-gain","display_name":"Body weight gain","entity_type_key":"cellular_process"},"role":"downstream_outcome","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f4a1a50c-5e9d-5f48-98e9-d9c808c7b73a","slug":"sr141716a","display_name":"SR141716A / rimonabant, a CB1 receptor antagonist","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"49de215e-5399-5593-9477-5a0e78dbe6be","slug":"food-intake","display_name":"Food intake","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/thc-research/9718088.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4714909d64a1c671c1c3dcec0496b80cc6a09e0a8d0368ed6b8be8aa284456e2\", \"start_char\": 0, \"end_char\": 590, \"text_sha256\": \"4714909d64a1c671c1c3dcec0496b80cc6a09e0a8d0368ed6b8be8aa284456e2\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"The CB1 antagonist SR141716 given for appetite and body weight measurement","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"SR141716 administration with food intake and weight measurement","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Establishes that blocking the receptor suppresses appetite, which is the mirror of the drug effect. Rimonabant was later withdrawn for psychiatric adverse effects, which is not in this record.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates.","comparator":null,"unit":null,"notes":"","entity":{"slug":"tetrahydrocannabinol","display_name":"Delta-9-tetrahydrocannabinol / THC","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Rodent","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Blocking the receptor takes hunger away, which is why the drug increases it.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[thc-p9718088] Appetite suppression and weight loss after the cannabinoid antagonist SR 141716. (1998). https://pubmed.ncbi.nlm.nih.gov/9718088/ DOI: 10.1016/s0024-3205(98)00322-1","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Whole body","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"1946fdf1-6c31-5757-9b68-cc12c0a8a318","evidence_kind":"source_excerpt","locator":"Lines 491-502","start_line":491,"end_line":502,"excerpt":"### thc-antagonist-suppresses-appetite\nAppetite suppression and weight loss followed administration of the cannabinoid antagonist SR141716.\nCondition category: normal\nnutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates.\nplain_language: Blocking the receptor takes hunger away, which is why the drug increases it.\norganism: Rodent\ntissue_or_cell_type: Whole body\nexperimental_model: The CB1 antagonist SR141716 given for appetite and body weight measurement\nlimitations: Establishes that blocking the receptor suppresses appetite, which is the mirror of the drug effect. Rimonabant was later withdrawn for psychiatric adverse effects, which is not in this record.\nexposure: SR141716 administration with food intake and weight measurement\nevidence_span: {\"source_cache\": \"artifacts/thc-research/9718088.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4714909d64a1c671c1c3dcec0496b80cc6a09e0a8d0368ed6b8be8aa284456e2\", \"start_char\": 0, \"end_char\": 590, \"text_sha256\": \"4714909d64a1c671c1c3dcec0496b80cc6a09e0a8d0368ed6b8be8aa284456e2\"}\n[thc-p9718088] Appetite suppression and weight loss after the cannabinoid antagonist SR 141716. (1998). https://pubmed.ncbi.nlm.nih.gov/9718088/ DOI: 10.1016/s0024-3205(98)00322-1","model_system":"The CB1 antagonist SR141716 given for appetite and body weight measurement","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [thc-p9718088] Appetite suppression and weight loss after the cannabinoid antagonist SR 141716. (1998). https://pubmed.ncbi.nlm.nih.gov/9718088/ DOI: 10.1016/s0024-3205(98)00322-1","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b4367320-9724-507a-bead-6932fa0a78cb","stable_key":"import-05a3cf47-e660-5ab3-8c32-5eba9847cf0a","title":"THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"60abc81737d18b7a50b01ca487e38291774ee15d9777651aa2d3eac8670ac3b2","revision_id":"2cba3552-af89-580d-b20a-8cfb1b14f9e7","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}