Component
FITC-conjugated folic acid
Fluorescent folic-acid probe used for imaging; distinct from native 5-methyltetrahydrofolate.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Human FOLR1 and FITC-conjugated folic acid moved together from basolateral to apical sides of polarized rat choroid-plexus cells.
Experimental context and source evidence
- evidence_location
- Figure 2: polarized FITC-folic-acid cotransport
- experimental_model
- Human FOLR1 in rat choroid-plexus cells, human CSF, mouse injections
- exposure
- Human FOLR1 transfection and FITC-folic-acid imaging
- limitations
- Engineered cellular barrier and fluorescent conjugate; not direct native-5-MTHF or whole-human transport measurement.
- nutrient_topic
- Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. · Folate (vitamin B9)
- organism
- Human protein in rat cells
- plain_language
- The receptor helped folate cross a modeled brain-fluid barrier.
- primary_references
- [grapp2013] Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma (2013). https://pubmed.ncbi.nlm.nih.gov/23828504/ DOI: 10.1038/ncomms3123
- tissue_or_cell_type
- Polarized choroid-plexus cells
Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 206–217
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human FOLR1 in rat choroid-plexus cells, human CSF, mouse injections · source_derived_draft · unverified_draft
### folate-fralpha-polarized-transfer Human FOLR1 and FITC-conjugated folic acid moved together from basolateral to apical sides of polarized rat choroid-plexus cells. Condition category: normal nutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: The receptor helped folate cross a modeled brain-fluid barrier. organism: Human protein in rat cells tissue_or_cell_type: Polarized choroid-plexus cells experimental_model: Human FOLR1 in rat choroid-plexus cells, human CSF, mouse injections limitations: Engineered cellular barrier and fluorescent conjugate; not direct native-5-MTHF or whole-human transport measurement. exposure: Human FOLR1 transfection and FITC-folic-acid imaging evidence_location: Figure 2: polarized FITC-folic-acid cotransport [grapp2013] Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma (2013). https://pubmed.ncbi.nlm.nih.gov/23828504/ DOI: 10.1038/ncomms3123
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.