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not direct native-5-MTHF or whole-human transport measurement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"folate","display_name":"Folate (vitamin B9)","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Human protein in rat cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The receptor helped folate cross a modeled brain-fluid barrier.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[grapp2013] Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma (2013). https://pubmed.ncbi.nlm.nih.gov/23828504/ DOI: 10.1038/ncomms3123","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Polarized choroid-plexus cells","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b417065c-7df1-5b2b-9a81-0bbf3b11c170","evidence_kind":"source_excerpt","locator":"Lines 206-217","start_line":206,"end_line":217,"excerpt":"### folate-fralpha-polarized-transfer\nHuman FOLR1 and FITC-conjugated folic acid moved together from basolateral to apical sides of polarized rat choroid-plexus cells.\nCondition category: normal\nnutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The receptor helped folate cross a modeled brain-fluid barrier.\norganism: Human protein in rat cells\ntissue_or_cell_type: Polarized choroid-plexus cells\nexperimental_model: Human FOLR1 in rat choroid-plexus cells, human CSF, mouse injections\nlimitations: Engineered cellular barrier and fluorescent conjugate; not direct native-5-MTHF or whole-human transport measurement.\nexposure: Human FOLR1 transfection and FITC-folic-acid imaging\nevidence_location: Figure 2: polarized FITC-folic-acid cotransport\n[grapp2013] Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma (2013). https://pubmed.ncbi.nlm.nih.gov/23828504/ DOI: 10.1038/ncomms3123","model_system":"Human FOLR1 in rat choroid-plexus cells, human CSF, mouse injections","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [grapp2013] Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma (2013). https://pubmed.ncbi.nlm.nih.gov/23828504/ DOI: 10.1038/ncomms3123","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"f4ce1a62-9582-5f7a-84f5-a23d0e1bfc68","stable_key":"import-ec174d5a-4903-5745-8646-df0e9d4265e8","title":"Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e564d43989ece1006c95cd0748e9af6fe369074599a2eebba0a99ebff864b0dd","revision_id":"76674a33-b2a1-5e41-b71b-44399038ff7c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}