Component
Gap junction communication in human skin fibroblasts
Gap junction communication in human skin fibroblasts. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Lycopene at 0.1 micromolar stimulated gap-junction communication in human fetal skin fibroblasts.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/lycopene-research/10620348.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dfd11c7c19dcd07e092a601ff44e9c900b5ecd717d3661ac2aca48d5cac72011", "start_char": 0, "end_char": 1295, "text_sha256": "dfd11c7c19dcd07e092a601ff44e9c900b5ecd717d3661ac2aca48d5cac72011"}
- experimental_model
- Gap-junction and promoter/mRNA assays
- exposure
- Lycopene 0.1 micromolar; acyclo-retinoic acid 1 or 50 micromolar depending on endpoint
- limitations
- Communication, mRNA stability and RAR reporter responses are distinct; very high metabolite doses are not physiological proof.
- nutrient_topic
- Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
- organism
- Human fetal skin fibroblasts and reporter systems
- plain_language
- Neighboring cells exchanged small signals more readily in this model.
- primary_references
- [lycopene-p10620348] Stimulation of gap junctional communication: comparison of acyclo-retinoic acid and lycopene. (2000). https://pubmed.ncbi.nlm.nih.gov/10620348/ DOI: 10.1006/abbi.1999.1510
- tissue_or_cell_type
- Connexin-related intercellular communication
Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 611–622
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Gap-junction and promoter/mRNA assays · source_derived_draft · unverified_draft
### lycopene-gap-junction Lycopene at 0.1 micromolar stimulated gap-junction communication in human fetal skin fibroblasts. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: Neighboring cells exchanged small signals more readily in this model. organism: Human fetal skin fibroblasts and reporter systems tissue_or_cell_type: Connexin-related intercellular communication experimental_model: Gap-junction and promoter/mRNA assays limitations: Communication, mRNA stability and RAR reporter responses are distinct; very high metabolite doses are not physiological proof. exposure: Lycopene 0.1 micromolar; acyclo-retinoic acid 1 or 50 micromolar depending on endpoint evidence_span: {"source_cache": "artifacts/lycopene-research/10620348.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dfd11c7c19dcd07e092a601ff44e9c900b5ecd717d3661ac2aca48d5cac72011", "start_char": 0, "end_char": 1295, "text_sha256": "dfd11c7c19dcd07e092a601ff44e9c900b5ecd717d3661ac2aca48d5cac72011"} [lycopene-p10620348] Stimulation of gap junctional communication: comparison of acyclo-retinoic acid and lycopene. (2000). https://pubmed.ncbi.nlm.nih.gov/10620348/ DOI: 10.1006/abbi.1999.1510
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.