Component
Ascorbate-driven reduction of ferric iron in vitro
Ascorbate-driven reduction of ferric iron in vitro. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Mangiferin prevented ascorbate-driven ferric iron reduction in vitro.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/mangiferin-research/15878708.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e29d024822df85f1aa0b737bb4123c869646d737c15bf05f1dc72b047a45eef3", "start_char": 0, "end_char": 1966, "text_sha256": "e29d024822df85f1aa0b737bb4123c869646d737c15bf05f1dc72b047a45eef3"}
- experimental_model
- Isolated mitochondrial and iron-redox assays
- exposure
- 10 micromolar mangiferin and 50 micromolar ferrous citrate in one protection experiment
- limitations
- In vitro iron complexing is not evidence that oral mangiferin depletes body iron or treats iron overload.
- nutrient_topic
- Mangiferin research collection; topical membership is not evidence of a direct dietary effect. · Mangiferin
- organism
- Rattus norvegicus and cell-free chemistry
- plain_language
- Iron binding changed a reaction involving vitamin C.
- primary_references
- [mangiferin-p15878708] Iron complexing activity of mangiferin, a naturally occurring glucosylxanthone, inhibits mitochondrial lipid peroxidation induced by Fe2+-citrate. (2005). https://pubmed.ncbi.nlm.nih.gov/15878708/ DOI: 10.1016/j.ejphar.2005.03.007
- tissue_or_cell_type
- Liver mitochondria
Mangiferin: metabolism, signaling and nutrient connections (2026-09-17) · lines 692–703
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Isolated mitochondrial and iron-redox assays · source_derived_draft · unverified_draft
### mangiferin-iron-vitamin-c Mangiferin prevented ascorbate-driven ferric iron reduction in vitro. Condition category: normal nutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Iron binding changed a reaction involving vitamin C. organism: Rattus norvegicus and cell-free chemistry tissue_or_cell_type: Liver mitochondria experimental_model: Isolated mitochondrial and iron-redox assays limitations: In vitro iron complexing is not evidence that oral mangiferin depletes body iron or treats iron overload. exposure: 10 micromolar mangiferin and 50 micromolar ferrous citrate in one protection experiment evidence_span: {"source_cache": "artifacts/mangiferin-research/15878708.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e29d024822df85f1aa0b737bb4123c869646d737c15bf05f1dc72b047a45eef3", "start_char": 0, "end_char": 1966, "text_sha256": "e29d024822df85f1aa0b737bb4123c869646d737c15bf05f1dc72b047a45eef3"} [mangiferin-p15878708] Iron complexing activity of mangiferin, a naturally occurring glucosylxanthone, inhibits mitochondrial lipid peroxidation induced by Fe2+-citrate. (2005). https://pubmed.ncbi.nlm.nih.gov/15878708/ DOI: 10.1016/j.ejphar.2005.03.007
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.