Component
Femoral arterial fluorine-18 sodium fluoride PET activity
Femoral arterial fluorine-18 sodium fluoride PET activity. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The between-group PET activity estimate favored an increase of 0.25 (95% CI -0.02 to 0.51; P=0.06); CT calcium-mass differences were also nonsignificant.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/k2-research/31387121.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "669c0cd660524535123c231e46bba36d26e632210055aa863a3601f3c7da9621", "start_char": 0, "end_char": 2207, "text_sha256": "669c0cd660524535123c231e46bba36d26e632210055aa863a3601f3c7da9621"}
- experimental_model
- Six-month randomized double-blind trial
- exposure
- MK-7 360 micrograms/day
- limitations
- Small trial, 60 completed; PET activity and CT calcium mass are distinct. A nonsignificant trend is not a demonstrated increase in disease.
- nutrient_topic
- Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
- organism
- 68 adults with type 2 diabetes and established cardiovascular disease
- plain_language
- This study did not show the hoped-for imaging improvement despite a better biomarker.
- primary_references
- [k2-p31387121] The effect of menaquinone-7 supplementation on vascular calcification in patients with diabetes: a randomized, double-blind, placebo-controlled trial. (2019). https://pubmed.ncbi.nlm.nih.gov/31387121/ DOI: 10.1093/ajcn/nqz147
- tissue_or_cell_type
- Femoral fluorine-18 NaF PET and CT
Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 1189–1200
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Six-month randomized double-blind trial · source_derived_draft · unverified_draft
### k2-diabetes-imaging The between-group PET activity estimate favored an increase of 0.25 (95% CI -0.02 to 0.51; P=0.06); CT calcium-mass differences were also nonsignificant. Condition category: normal nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: This study did not show the hoped-for imaging improvement despite a better biomarker. organism: 68 adults with type 2 diabetes and established cardiovascular disease tissue_or_cell_type: Femoral fluorine-18 NaF PET and CT experimental_model: Six-month randomized double-blind trial limitations: Small trial, 60 completed; PET activity and CT calcium mass are distinct. A nonsignificant trend is not a demonstrated increase in disease. exposure: MK-7 360 micrograms/day evidence_span: {"source_cache": "artifacts/k2-research/31387121.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "669c0cd660524535123c231e46bba36d26e632210055aa863a3601f3c7da9621", "start_char": 0, "end_char": 2207, "text_sha256": "669c0cd660524535123c231e46bba36d26e632210055aa863a3601f3c7da9621"} [k2-p31387121] The effect of menaquinone-7 supplementation on vascular calcification in patients with diabetes: a randomized, double-blind, placebo-controlled trial. (2019). https://pubmed.ncbi.nlm.nih.gov/31387121/ DOI: 10.1093/ajcn/nqz147
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.