Component

Fasting plasma insulin concentration

Fasting plasma insulin concentration. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Fasting and two-hour insulin measurements decreased in both chromium-supplemented groups in the reported study.

    Chromium(III) picolinate / CrPic → Fasting plasma insulin concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/chromium-research/9356027.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9c9f5146517d1c6967a6f75951c79fbb828408e96693be5df98f9fb1ec91aa69", "start_char": 0, "end_char": 1941, "text_sha256": "9c9f5146517d1c6967a6f75951c79fbb828408e96693be5df98f9fb1ec91aa69"}
    experimental_model
    Randomized three-arm supplementation trial; 180 adults
    exposure
    Placebo, 200 or 1,000 µg Cr/day as picolinate for four months while usual medications continued
    limitations
    Historical single-population trial; response does not diagnose chromium deficiency. Baseline diet, medication context and replication matter; later trials reported null effects.
    nutrient_topic
    Chromium research collection; topical membership is not evidence of a direct dietary effect. · Chromium
    organism
    Human with treated type 2 diabetes
    plain_language
    The study reported an insulin change alongside its glucose findings.
    primary_references
    [chromium-p9356027] Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. (1997). https://pubmed.ncbi.nlm.nih.gov/9356027/ DOI: 10.2337/diab.46.11.1786
    tissue_or_cell_type
    HbA1c, glucose, insulin and lipids

    Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17) · lines 1043–1054

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized three-arm supplementation trial; 180 adults · source_derived_draft · unverified_draft

    ### chromium-diabetes-insulin-positive Fasting and two-hour insulin measurements decreased in both chromium-supplemented groups in the reported study. Condition category: normal nutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect. plain_language: The study reported an insulin change alongside its glucose findings. organism: Human with treated type 2 diabetes tissue_or_cell_type: HbA1c, glucose, insulin and lipids experimental_model: Randomized three-arm supplementation trial; 180 adults limitations: Historical single-population trial; response does not diagnose chromium deficiency. Baseline diet, medication context and replication matter; later trials reported null effects. exposure: Placebo, 200 or 1,000 µg Cr/day as picolinate for four months while usual medications continued evidence_span: {"source_cache": "artifacts/chromium-research/9356027.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9c9f5146517d1c6967a6f75951c79fbb828408e96693be5df98f9fb1ec91aa69", "start_char": 0, "end_char": 1941, "text_sha256": "9c9f5146517d1c6967a6f75951c79fbb828408e96693be5df98f9fb1ec91aa69"} [chromium-p9356027] Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. (1997). https://pubmed.ncbi.nlm.nih.gov/9356027/ DOI: 10.2337/diab.46.11.1786
    Complete structured claim and evidence

  2. The low-chromium group had higher fasting insulin and higher insulin at 30 and 60 minutes after glucose than the normal-chromium group, without a difference in glucose levels.

    Chromium → Fasting plasma insulin concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/chromium-research/36701335.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "762bdd075019b97831308c39060063214abcb5c5075bfc69afd9b1e250b41a48", "start_char": 0, "end_char": 1806, "text_sha256": "762bdd075019b97831308c39060063214abcb5c5075bfc69afd9b1e250b41a48"}
    experimental_model
    Twelve-week dietary chromium experiment in both sexes
    exposure
    From day 35 of age; moderately high-fat/high-sucrose diets with 0.33, 1.20 or 9.15 mg Cr/kg; 10 males and 10 females/group
    limitations
    Different diet, strain and duration from the 2011 study. Greater food intake can contribute to adiposity and insulin changes. Low is relative to this rodent formulation, not a human deficiency cutoff.
    nutrient_topic
    Chromium research collection; topical membership is not evidence of a direct dietary effect. · Chromium
    organism
    Sprague-Dawley CD rats
    plain_language
    The animals needed a different insulin response while measured glucose stayed similar.
    primary_references
    [chromium-p36701335] A low chromium diet increases body fat, energy intake and circulating triglycerides and insulin in male and female rats fed a moderately high-fat, high-sucrose diet from peripuberty to young adult age. (2023). https://pubmed.ncbi.nlm.nih.gov/36701335/ DOI: 10.1371/journal.pone.0281019
    tissue_or_cell_type
    Whole-body fat and circulating metabolic measures
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17) · lines 978–989

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Twelve-week dietary chromium experiment in both sexes · source_derived_draft · unverified_draft

    ### chromium-low-diet-insulin-2023 The low-chromium group had higher fasting insulin and higher insulin at 30 and 60 minutes after glucose than the normal-chromium group, without a difference in glucose levels. Condition category: nutrient_deficiency nutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect. plain_language: The animals needed a different insulin response while measured glucose stayed similar. organism: Sprague-Dawley CD rats tissue_or_cell_type: Whole-body fat and circulating metabolic measures experimental_model: Twelve-week dietary chromium experiment in both sexes limitations: Different diet, strain and duration from the 2011 study. Greater food intake can contribute to adiposity and insulin changes. Low is relative to this rodent formulation, not a human deficiency cutoff. exposure: From day 35 of age; moderately high-fat/high-sucrose diets with 0.33, 1.20 or 9.15 mg Cr/kg; 10 males and 10 females/group evidence_span: {"source_cache": "artifacts/chromium-research/36701335.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "762bdd075019b97831308c39060063214abcb5c5075bfc69afd9b1e250b41a48", "start_char": 0, "end_char": 1806, "text_sha256": "762bdd075019b97831308c39060063214abcb5c5075bfc69afd9b1e250b41a48"} [chromium-p36701335] A low chromium diet increases body fat, energy intake and circulating triglycerides and insulin in male and female rats fed a moderately high-fat, high-sucrose diet from peripuberty to young adult age. (2023). https://pubmed.ncbi.nlm.nih.gov/36701335/ DOI: 10.1371/journal.pone.0281019
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards