Etoposide: molecular mechanisms & dependencies

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

Where it participates (unsigned role)

Mangiferin reduced etoposide-associated comet and micronucleus damage readouts.
Mangiferin → Etoposide-associated DNA damage in human cord-blood mononuclear cells source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/mangiferin-research/25380307.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "057a534a2074c49c824120d8e49fba7f4bde4d9d9b8bf15ef78f994083fdc8ea", "start_char": 0, "end_char": 1636, "text_sha256": "057a534a2074c49c824120d8e49fba7f4bde4d9d9b8bf15ef78f994083fdc8ea"}
experimental_model
Isolated human cord-blood mononuclear cells
exposure
Mangiferin and etoposide; concentration not specified in indexed abstract
limitations
Ex vivo DNA-damage and signaling assays; not evidence of clinical chemotherapy protection.
nutrient_topic
Mangiferin research collection; topical membership is not evidence of a direct dietary effect. · Mangiferin
organism
Homo sapiens
plain_language
DNA-damage measurements were lower in these isolated cells.
primary_references
[mangiferin-p25380307] Mangiferin activates the Nrf2-ARE pathway and reduces etoposide-induced DNA damage in human umbilical cord mononuclear blood cells. (2015). https://pubmed.ncbi.nlm.nih.gov/25380307/ DOI: 10.3109/13880209.2014.927890
tissue_or_cell_type
Cord-blood mononuclear cells
Mangiferin: metabolism, signaling and nutrient connections (2026-09-17) · lines 588–599
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Isolated human cord-blood mononuclear cells · source_derived_draft · unverified_draft
### mangiferin-dna-damage Mangiferin reduced etoposide-associated comet and micronucleus damage readouts. Condition category: normal nutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect. plain_language: DNA-damage measurements were lower in these isolated cells. organism: Homo sapiens tissue_or_cell_type: Cord-blood mononuclear cells experimental_model: Isolated human cord-blood mononuclear cells limitations: Ex vivo DNA-damage and signaling assays; not evidence of clinical chemotherapy protection. exposure: Mangiferin and etoposide; concentration not specified in indexed abstract evidence_span: {"source_cache": "artifacts/mangiferin-research/25380307.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "057a534a2074c49c824120d8e49fba7f4bde4d9d9b8bf15ef78f994083fdc8ea", "start_char": 0, "end_char": 1636, "text_sha256": "057a534a2074c49c824120d8e49fba7f4bde4d9d9b8bf15ef78f994083fdc8ea"} [mangiferin-p25380307] Mangiferin activates the Nrf2-ARE pathway and reduces etoposide-induced DNA damage in human umbilical cord mononuclear blood cells. (2015). https://pubmed.ncbi.nlm.nih.gov/25380307/ DOI: 10.3109/13880209.2014.927890
Complete structured claim and evidence
Mangiferin did not attenuate etoposide cytotoxicity in HL-60 cells, despite protecting cord-blood mononuclear cells in the comparison.
Mangiferin → Etoposide-associated cytotoxicity in human HL-60 cells source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/mangiferin-research/24374812.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "85ad69fcef2b1dd7b3842c076b89b76c9d54b73cc5843cefb3077642b6cb3451", "start_char": 0, "end_char": 1789, "text_sha256": "85ad69fcef2b1dd7b3842c076b89b76c9d54b73cc5843cefb3077642b6cb3451"}
experimental_model
Cell-line and primary mononuclear-cell comparison
exposure
Mangiferin 50 micromolar in principal assays; etoposide co-exposure
limitations
No clinical chemotherapy outcome. The abstract has an inconsistent mol/L unit in a later sentence; the 50 micromolar experimental concentration is explicit earlier.
nutrient_topic
Mangiferin research collection; topical membership is not evidence of a direct dietary effect. · Mangiferin
organism
Homo sapiens
plain_language
Protection varied with cell type.
primary_references
[mangiferin-p24374812] Mangiferin activates Nrf2-antioxidant response element signaling without reducing the sensitivity to etoposide of human myeloid leukemia cells in vitro. (2014). https://pubmed.ncbi.nlm.nih.gov/24374812/ DOI: 10.1038/aps.2013.165
tissue_or_cell_type
HL-60 leukemia cells and cord-blood mononuclear cells
Mangiferin: metabolism, signaling and nutrient connections (2026-09-17) · lines 1303–1314
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cell-line and primary mononuclear-cell comparison · source_derived_draft · unverified_draft
### mangiferin-etoposide-cell-context Mangiferin did not attenuate etoposide cytotoxicity in HL-60 cells, despite protecting cord-blood mononuclear cells in the comparison. Condition category: normal nutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Protection varied with cell type. organism: Homo sapiens tissue_or_cell_type: HL-60 leukemia cells and cord-blood mononuclear cells experimental_model: Cell-line and primary mononuclear-cell comparison limitations: No clinical chemotherapy outcome. The abstract has an inconsistent mol/L unit in a later sentence; the 50 micromolar experimental concentration is explicit earlier. exposure: Mangiferin 50 micromolar in principal assays; etoposide co-exposure evidence_span: {"source_cache": "artifacts/mangiferin-research/24374812.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "85ad69fcef2b1dd7b3842c076b89b76c9d54b73cc5843cefb3077642b6cb3451", "start_char": 0, "end_char": 1789, "text_sha256": "85ad69fcef2b1dd7b3842c076b89b76c9d54b73cc5843cefb3077642b6cb3451"} [mangiferin-p24374812] Mangiferin activates Nrf2-antioxidant response element signaling without reducing the sensitivity to etoposide of human myeloid leukemia cells in vitro. (2014). https://pubmed.ncbi.nlm.nih.gov/24374812/ DOI: 10.1038/aps.2013.165
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

Etoposide