Component

Ethylamine

Ethylamine. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

Where it participates (unsigned role)

  1. Plasma ethylamine increased after theanine ingestion, consistent with hydrolysis of the parent compound.

    L-Theanine → Plasma ethylamine concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/theanine-research/23096008.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0080959c2621f814538b812413bd295d2fdab96bc401c2ed1876fc2e1044406a", "start_char": 0, "end_char": 1696, "text_sha256": "0080959c2621f814538b812413bd295d2fdab96bc401c2ed1876fc2e1044406a"}
    experimental_model
    Randomized crossover absorption and metabolite study
    exposure
    100 mg theanine as capsule or green tea; subset 50 and 200 mg
    limitations
    Small acute study; plasma concentration does not identify brain concentration or clinical response. Tea preparation was specific to this experiment.
    nutrient_topic
    L-Theanine research collection; topical membership is not evidence of a direct dietary effect. · L-Theanine
    organism
    Twelve healthy humans; dose-ranging subset of three
    plain_language
    Its breakdown products have identities separate from the ingested molecule.
    primary_references
    [theanine-p23096008] Kinetics of L-theanine uptake and metabolism in healthy participants are comparable after ingestion of L-theanine via capsules and green tea. (2012). https://pubmed.ncbi.nlm.nih.gov/23096008/ DOI: 10.3945/jn.112.166371
    tissue_or_cell_type
    Plasma, erythrocytes and urine

    L-Theanine: metabolism, neural signaling, nutrient connections and human outcomes (2026-09-17) · lines 120–131

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized crossover absorption and metabolite study · source_derived_draft · unverified_draft

    ### theanine-human-ethylamine Plasma ethylamine increased after theanine ingestion, consistent with hydrolysis of the parent compound. Condition category: normal nutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Its breakdown products have identities separate from the ingested molecule. organism: Twelve healthy humans; dose-ranging subset of three tissue_or_cell_type: Plasma, erythrocytes and urine experimental_model: Randomized crossover absorption and metabolite study limitations: Small acute study; plasma concentration does not identify brain concentration or clinical response. Tea preparation was specific to this experiment. exposure: 100 mg theanine as capsule or green tea; subset 50 and 200 mg evidence_span: {"source_cache": "artifacts/theanine-research/23096008.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0080959c2621f814538b812413bd295d2fdab96bc401c2ed1876fc2e1044406a", "start_char": 0, "end_char": 1696, "text_sha256": "0080959c2621f814538b812413bd295d2fdab96bc401c2ed1876fc2e1044406a"} [theanine-p23096008] Kinetics of L-theanine uptake and metabolism in healthy participants are comparable after ingestion of L-theanine via capsules and green tea. (2012). https://pubmed.ncbi.nlm.nih.gov/23096008/ DOI: 10.3945/jn.112.166371
    Complete structured claim and evidence

  2. Theanine-degrading activity copurified with rat renal phosphate-independent glutaminase activity.

    Rat renal phosphate-independent glutaminase preparation, gene identity unresolved → L-Theanine source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/theanine-research/12595072.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8a9ae8e6ba86ea3e06440e972c30ca28685032dc3b9cd74c2d98311715c2435e", "start_char": 0, "end_char": 1324, "text_sha256": "8a9ae8e6ba86ea3e06440e972c30ca28685032dc3b9cd74c2d98311715c2435e"}
    experimental_model
    Renal enzyme purification and substrate-specificity assays
    exposure
    Theanine and glutamine substrates; phosphate-dependent versus independent preparations
    limitations
    Assay-defined enzyme identity is not assigned to human GLS or GLS2. Rat tissue distribution does not prove the human kidney is the exclusive metabolic site.
    nutrient_topic
    L-Theanine research collection; topical membership is not evidence of a direct dietary effect. · L-Theanine
    organism
    Wistar rat tissue and purified enzyme preparations
    plain_language
    One renal enzyme preparation broke down theanine; it must not be confused with every glutaminase.
    primary_references
    [theanine-p12595072] Theanine, gamma-glutamylethylamide, is metabolized by renal phosphate-independent glutaminase. (2003). https://pubmed.ncbi.nlm.nih.gov/12595072/ DOI: 10.1016/s0304-4165(02)00504-4
    tissue_or_cell_type
    Kidney hydrolysis and gamma-glutamyl transfer

    L-Theanine: metabolism, neural signaling, nutrient connections and human outcomes (2026-09-17) · lines 146–157

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Renal enzyme purification and substrate-specificity assays · source_derived_draft · unverified_draft

    ### theanine-renal-enzyme Theanine-degrading activity copurified with rat renal phosphate-independent glutaminase activity. Condition category: normal nutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect. plain_language: One renal enzyme preparation broke down theanine; it must not be confused with every glutaminase. organism: Wistar rat tissue and purified enzyme preparations tissue_or_cell_type: Kidney hydrolysis and gamma-glutamyl transfer experimental_model: Renal enzyme purification and substrate-specificity assays limitations: Assay-defined enzyme identity is not assigned to human GLS or GLS2. Rat tissue distribution does not prove the human kidney is the exclusive metabolic site. exposure: Theanine and glutamine substrates; phosphate-dependent versus independent preparations evidence_span: {"source_cache": "artifacts/theanine-research/12595072.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8a9ae8e6ba86ea3e06440e972c30ca28685032dc3b9cd74c2d98311715c2435e", "start_char": 0, "end_char": 1324, "text_sha256": "8a9ae8e6ba86ea3e06440e972c30ca28685032dc3b9cd74c2d98311715c2435e"} [theanine-p12595072] Theanine, gamma-glutamylethylamide, is metabolized by renal phosphate-independent glutaminase. (2003). https://pubmed.ncbi.nlm.nih.gov/12595072/ DOI: 10.1016/s0304-4165(02)00504-4
    Complete structured claim and evidence

  3. Tea consumption primed peripheral gamma-delta T-cell recall responses to ethylamine.

    Tea beverage, study-specific composition → Human gamma-delta T-cell recall response source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/theanine-research/12719524.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5597ffe96859e7675adb765468cef7d5809b7874501b43cff49a1c4b866987b9", "start_char": 0, "end_char": 1161, "text_sha256": "5597ffe96859e7675adb765468cef7d5809b7874501b43cff49a1c4b866987b9"}
    experimental_model
    Human cell priming and tea-consumption immune assays
    exposure
    Alkylamine priming in vitro; tea consumption in humans
    limitations
    Tea has many constituents. The study does not isolate theanine as the cause or establish clinical infection prevention.
    nutrient_topic
    L-Theanine research collection; topical membership is not evidence of a direct dietary effect. · L-Theanine
    organism
    Human gamma-delta T cells and tea drinkers
    plain_language
    A theanine metabolite connects to a measured immune response, but the intervention was tea.
    primary_references
    [theanine-p12719524] Antigens in tea-beverage prime human Vgamma 2Vdelta 2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses. (2003). https://pubmed.ncbi.nlm.nih.gov/12719524/ DOI: 10.1073/pnas.1035603100
    tissue_or_cell_type
    Ex-vivo immune response to ethylamine and bacteria

    L-Theanine: metabolism, neural signaling, nutrient connections and human outcomes (2026-09-17) · lines 848–859

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human cell priming and tea-consumption immune assays · source_derived_draft · unverified_draft

    ### theanine-tea-ethylamine-recall Tea consumption primed peripheral gamma-delta T-cell recall responses to ethylamine. Condition category: normal nutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect. plain_language: A theanine metabolite connects to a measured immune response, but the intervention was tea. organism: Human gamma-delta T cells and tea drinkers tissue_or_cell_type: Ex-vivo immune response to ethylamine and bacteria experimental_model: Human cell priming and tea-consumption immune assays limitations: Tea has many constituents. The study does not isolate theanine as the cause or establish clinical infection prevention. exposure: Alkylamine priming in vitro; tea consumption in humans evidence_span: {"source_cache": "artifacts/theanine-research/12719524.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5597ffe96859e7675adb765468cef7d5809b7874501b43cff49a1c4b866987b9", "start_char": 0, "end_char": 1161, "text_sha256": "5597ffe96859e7675adb765468cef7d5809b7874501b43cff49a1c4b866987b9"} [theanine-p12719524] Antigens in tea-beverage prime human Vgamma 2Vdelta 2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses. (2003). https://pubmed.ncbi.nlm.nih.gov/12719524/ DOI: 10.1073/pnas.1035603100
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards