Component
Erythroid heme synthesis
Erythroid heme synthesis. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Mfrn-null mouse embryonic-stem-cell-derived erythroblasts arrested maturation and had severely impaired incorporation of iron-55 into heme.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/iron-research/16511496.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cb2b06715c001133d1f1173d5084a2689170fa9a0e14f3b7b0a0cb5a7b6a5234", "start_char": 0, "end_char": 1533, "text_sha256": "cb2b06715c001133d1f1173d5084a2689170fa9a0e14f3b7b0a0cb5a7b6a5234"}
- experimental_model
- Zebrafish mutant, mouse stem-cell knockout and cross-species rescue
- exposure
- Mitoferrin loss and rescue
- limitations
- Species-specific loss/rescue evidence; no claim that plasma iron alone measures mitochondrial iron delivery.
- nutrient_topic
- Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
- organism
- Zebrafish, mice and yeast
- plain_language
- Plenty of iron elsewhere would not replace this missing mitochondrial transport step.
- primary_references
- [iron-p16511496] Mitoferrin is essential for erythroid iron assimilation. (2006). https://pubmed.ncbi.nlm.nih.gov/16511496/ DOI: 10.1038/nature04512
- tissue_or_cell_type
- Developing erythroblasts and mitochondria
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 472–483
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Zebrafish mutant, mouse stem-cell knockout and cross-species rescue · source_derived_draft · unverified_draft
### iron-mitoferrin-loss Mfrn-null mouse embryonic-stem-cell-derived erythroblasts arrested maturation and had severely impaired incorporation of iron-55 into heme. Condition category: machinery_impairment nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: Plenty of iron elsewhere would not replace this missing mitochondrial transport step. organism: Zebrafish, mice and yeast tissue_or_cell_type: Developing erythroblasts and mitochondria experimental_model: Zebrafish mutant, mouse stem-cell knockout and cross-species rescue limitations: Species-specific loss/rescue evidence; no claim that plasma iron alone measures mitochondrial iron delivery. exposure: Mitoferrin loss and rescue evidence_span: {"source_cache": "artifacts/iron-research/16511496.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cb2b06715c001133d1f1173d5084a2689170fa9a0e14f3b7b0a0cb5a7b6a5234", "start_char": 0, "end_char": 1533, "text_sha256": "cb2b06715c001133d1f1173d5084a2689170fa9a0e14f3b7b0a0cb5a7b6a5234"} [iron-p16511496] Mitoferrin is essential for erythroid iron assimilation. (2006). https://pubmed.ncbi.nlm.nih.gov/16511496/ DOI: 10.1038/nature04512
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.