Component

Erythrocyte pyridoxal 5-prime-phosphate concentration

Independently recorded entity or measured process. Linked claims specify compartment, assay and experimental scope.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

Where it participates (unsigned role)

  1. RA patients had lower plasma PLP than controls but no significant difference in erythrocyte PLP, AST activation coefficient or urinary 4-pyridoxic acid.

    Rheumatoid arthritis disease activity → Plasma pyridoxal 5-prime-phosphate concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    experimental_model
    Human cross-sectional comparison: 33 RA patients, 17 healthy controls; separate pair-fed rat adjuvant-arthritis experiment.
    exposure
    Human observational samples; rats studied at peak day 21 and chronic day 42 inflammation. Human arm shares recruitment program with supplementation study.
    limitations
    Cross-sectional association; disease, treatment and nutrition are not fully separable. Shared recruitment with related 2005 trial.
    nutrient_topic
    Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B6
    organism
    Homo sapiens
    plain_language
    A low blood-plasma result did not mean that every measured B6 compartment was low.
    primary_references
    [b6-chiang2005-inflammation] Inflammation causes tissue-specific depletion of vitamin B6 (2005). https://pubmed.ncbi.nlm.nih.gov/16277678/ DOI: 10.1186/ar1821
    tissue_or_cell_type
    Human blood and whole-body measurements
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1523–1533

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human cross-sectional comparison: 33 RA patients, 17 healthy controls; separate pair-fed rat adjuvant-arthritis experiment. · source_derived_draft · unverified_draft

    ### b6-ra-plasma-redcell-divergence RA patients had lower plasma PLP than controls but no significant difference in erythrocyte PLP, AST activation coefficient or urinary 4-pyridoxic acid. Condition category: biomarker_context nutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. plain_language: A low blood-plasma result did not mean that every measured B6 compartment was low. organism: Homo sapiens tissue_or_cell_type: Human blood and whole-body measurements experimental_model: Human cross-sectional comparison: 33 RA patients, 17 healthy controls; separate pair-fed rat adjuvant-arthritis experiment. limitations: Cross-sectional association; disease, treatment and nutrition are not fully separable. Shared recruitment with related 2005 trial. exposure: Human observational samples; rats studied at peak day 21 and chronic day 42 inflammation. Human arm shares recruitment program with supplementation study. [b6-chiang2005-inflammation] Inflammation causes tissue-specific depletion of vitamin B6 (2005). https://pubmed.ncbi.nlm.nih.gov/16277678/ DOI: 10.1186/ar1821
    Complete structured claim and evidence

  2. Supplementation improved plasma and erythrocyte PLP compared with placebo.

    Pyridoxine → Plasma pyridoxal 5-prime-phosphate concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    experimental_model
    Double-blind randomized placebo-controlled RA trial: 36 recruited, 33 baseline completers, 28 low-PLP patients eligible for supplementation.
    exposure
    Pyridoxine hydrochloride 50 mg/day or placebo for 30 days; historical trial exposure, not a regimen recommendation.
    limitations
    Selected low-PLP RA patients; blood response is not direct all-organ cofactor measurement.
    nutrient_topic
    Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B6
    organism
    Homo sapiens
    plain_language
    The measured B6 pools responded to added pyridoxine.
    primary_references
    [b6-chiang2005-trial] Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis (2005). https://pubmed.ncbi.nlm.nih.gov/16277693/ DOI: 10.1186/ar1839
    tissue_or_cell_type
    Human blood and whole-body measurements
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1461–1471

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind randomized placebo-controlled RA trial: 36 recruited, 33 baseline completers, 28 low-PLP patients eligible for supplementation. · source_derived_draft · unverified_draft

    ### b6-ra-vitamer-response Supplementation improved plasma and erythrocyte PLP compared with placebo. Condition category: biomarker_context nutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The measured B6 pools responded to added pyridoxine. organism: Homo sapiens tissue_or_cell_type: Human blood and whole-body measurements experimental_model: Double-blind randomized placebo-controlled RA trial: 36 recruited, 33 baseline completers, 28 low-PLP patients eligible for supplementation. limitations: Selected low-PLP RA patients; blood response is not direct all-organ cofactor measurement. exposure: Pyridoxine hydrochloride 50 mg/day or placebo for 30 days; historical trial exposure, not a regimen recommendation. [b6-chiang2005-trial] Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis (2005). https://pubmed.ncbi.nlm.nih.gov/16277693/ DOI: 10.1186/ar1839
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards