{"id":"4f3a75c0-268e-5384-b838-501016f6c4ff","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-ra-plasma-redcell-divergence","predicate":"associated_with_lower_plasma_but_not_redcell_plp","statement":"RA patients had lower plasma PLP than controls but no significant difference in erythrocyte PLP, AST activation coefficient or urinary 4-pyridoxic acid.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"b0dff424-e57b-5d13-8268-496dca0612b4","mechanism_event_label":"A low blood-plasma result did not mean that every measured B6 compartment was low.","subject":{"id":"631f2e58-aba7-5af2-8e4f-b31b3080a097","slug":"rheumatoid-arthritis-disease-activity","display_name":"Rheumatoid arthritis disease activity","entity_type_key":"cellular_process"},"object":{"id":"9907fbab-5dff-5e65-8891-1619ce01a4e2","slug":"plasma-plp-concentration","display_name":"Plasma pyridoxal 5-prime-phosphate concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b0dff424-e57b-5d13-8268-496dca0612b4","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-ra-plasma-redcell-divergence-event","event_type":"observed_intervention","label":"A low blood-plasma result did not mean that every measured B6 compartment was low.","description":"RA patients had lower plasma PLP than controls but no significant difference in erythrocyte PLP, AST activation coefficient or urinary 4-pyridoxic acid.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c6183463-b073-556e-8009-4450f6b2fb22","slug":"erythrocyte-plp-concentration","display_name":"Erythrocyte pyridoxal 5-prime-phosphate concentration","entity_type_key":"cellular_process"},"role":"contrasting_pool","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"befbcf98-c6a9-5b72-a039-2d6b9f3bde12","slug":"4-pyridoxic-acid","display_name":"4-Pyridoxic acid","entity_type_key":"small_molecule"},"role":"urinary_marker","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"631f2e58-aba7-5af2-8e4f-b31b3080a097","slug":"rheumatoid-arthritis-disease-activity","display_name":"Rheumatoid arthritis disease activity","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9907fbab-5dff-5e65-8891-1619ce01a4e2","slug":"plasma-plp-concentration","display_name":"Plasma pyridoxal 5-prime-phosphate concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Human cross-sectional comparison: 33 RA patients, 17 healthy controls; separate pair-fed rat adjuvant-arthritis experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Human observational samples; rats studied at peak day 21 and chronic day 42 inflammation. Human arm shares recruitment program with supplementation study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cross-sectional association; disease, treatment and nutrition are not fully separable. Shared recruitment with related 2005 trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A low blood-plasma result did not mean that every measured B6 compartment was low.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b6-chiang2005-inflammation] Inflammation causes tissue-specific depletion of vitamin B6 (2005). https://pubmed.ncbi.nlm.nih.gov/16277678/ DOI: 10.1186/ar1821","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human blood and whole-body measurements","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"77ba0254-38b8-5530-a383-0f7a1f3393ba","evidence_kind":"source_excerpt","locator":"Lines 1523-1533","start_line":1523,"end_line":1533,"excerpt":"### b6-ra-plasma-redcell-divergence\nRA patients had lower plasma PLP than controls but no significant difference in erythrocyte PLP, AST activation coefficient or urinary 4-pyridoxic acid.\nCondition category: biomarker_context\nnutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A low blood-plasma result did not mean that every measured B6 compartment was low.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood and whole-body measurements\nexperimental_model: Human cross-sectional comparison: 33 RA patients, 17 healthy controls; separate pair-fed rat adjuvant-arthritis experiment.\nlimitations: Cross-sectional association; disease, treatment and nutrition are not fully separable. Shared recruitment with related 2005 trial.\nexposure: Human observational samples; rats studied at peak day 21 and chronic day 42 inflammation. Human arm shares recruitment program with supplementation study.\n[b6-chiang2005-inflammation] Inflammation causes tissue-specific depletion of vitamin B6 (2005). https://pubmed.ncbi.nlm.nih.gov/16277678/ DOI: 10.1186/ar1821","model_system":"Human cross-sectional comparison: 33 RA patients, 17 healthy controls; separate pair-fed rat adjuvant-arthritis experiment.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b6-chiang2005-inflammation] Inflammation causes tissue-specific depletion of vitamin B6 (2005). https://pubmed.ncbi.nlm.nih.gov/16277678/ DOI: 10.1186/ar1821","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"251773bb-16f5-5903-b135-db4a61d9dec4","stable_key":"import-1310afbd-6010-586e-805d-551d846da421","title":"Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ef0019b344b2219220f801a84d0d138ff6880c1be1a59540d9034bfa4334f61e","revision_id":"cac3555f-48af-5c52-a84e-add4482c87fb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}