{"id":"67ddf421-9579-5c31-b147-a6ce57707003","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-ra-vitamer-response","predicate":"increased_plasma_and_erythrocyte_plp","statement":"Supplementation improved plasma and erythrocyte PLP compared with placebo.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"22a7c5f8-cc35-5f39-aeae-d140a3e1c6d9","mechanism_event_label":"The measured B6 pools responded to added pyridoxine.","subject":{"id":"aa6648f2-8962-5567-9939-ef4145e40ed1","slug":"pyridoxine","display_name":"Pyridoxine","entity_type_key":"small_molecule"},"object":{"id":"9907fbab-5dff-5e65-8891-1619ce01a4e2","slug":"plasma-plp-concentration","display_name":"Plasma pyridoxal 5-prime-phosphate concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"22a7c5f8-cc35-5f39-aeae-d140a3e1c6d9","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-ra-vitamer-response-event","event_type":"observed_intervention","label":"The measured B6 pools responded to added pyridoxine.","description":"Supplementation improved plasma and erythrocyte PLP compared with placebo.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c6183463-b073-556e-8009-4450f6b2fb22","slug":"erythrocyte-plp-concentration","display_name":"Erythrocyte pyridoxal 5-prime-phosphate concentration","entity_type_key":"cellular_process"},"role":"measured_marker","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"aa6648f2-8962-5567-9939-ef4145e40ed1","slug":"pyridoxine","display_name":"Pyridoxine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9907fbab-5dff-5e65-8891-1619ce01a4e2","slug":"plasma-plp-concentration","display_name":"Plasma pyridoxal 5-prime-phosphate concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; 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Study references: [b6-chiang2005-trial] Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis (2005). https://pubmed.ncbi.nlm.nih.gov/16277693/ DOI: 10.1186/ar1839","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"251773bb-16f5-5903-b135-db4a61d9dec4","stable_key":"import-1310afbd-6010-586e-805d-551d846da421","title":"Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ef0019b344b2219220f801a84d0d138ff6880c1be1a59540d9034bfa4334f61e","revision_id":"cac3555f-48af-5c52-a84e-add4482c87fb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}