Component

Erythrocyte peroxide-induced hemolysis

Erythrocyte peroxide-induced hemolysis. Read linked claims for the population, experiment and limits.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. In the historical premature-infant series, blood vitamin E below 0.6 mg/100 mL was associated with greater hydrogen-peroxide-induced erythrocyte hemolysis.

    Circulating alpha-tocopherol concentration → Erythrocyte peroxide-induced hemolysis source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    cross_nutrient
    false
    experimental_model
    Historical clinical series of 50 premature infants aged 6–8 weeks
    exposure
    Blood vitamin E and hydrogen-peroxide hemolysis were assessed; oral vitamin E 10 mg/day was administered.
    limitations
    Historical feeding conditions and infant ages; an ex vivo hemolysis assay is not a universal explanation for anemia of prematurity. Formulation not specified in the abstract. The reported concentration is specific to this study, not a universal cellular adequacy threshold.
    nutrient_topic
    Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
    organism
    Homo sapiens
    plain_language
    In this infant study, a low vitamin E reading accompanied fragile red cells in a peroxide test.
    primary_references
    [e-clin-lo1973] Vitamin E and haemolytic anaemia in premature infants. (1973). https://pubmed.ncbi.nlm.nih.gov/4739911/ DOI: 10.1136/adc.48.5.360
    tissue_or_cell_type
    Blood and erythrocytes
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 1193–1204

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Historical clinical series of 50 premature infants aged 6–8 weeks · source_derived_draft · unverified_draft

    ### e-clin-infant-peroxide-association In the historical premature-infant series, blood vitamin E below 0.6 mg/100 mL was associated with greater hydrogen-peroxide-induced erythrocyte hemolysis. Condition category: biomarker_context nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: In this infant study, a low vitamin E reading accompanied fragile red cells in a peroxide test. organism: Homo sapiens tissue_or_cell_type: Blood and erythrocytes experimental_model: Historical clinical series of 50 premature infants aged 6–8 weeks limitations: Historical feeding conditions and infant ages; an ex vivo hemolysis assay is not a universal explanation for anemia of prematurity. Formulation not specified in the abstract. The reported concentration is specific to this study, not a universal cellular adequacy threshold. exposure: Blood vitamin E and hydrogen-peroxide hemolysis were assessed; oral vitamin E 10 mg/day was administered. cross_nutrient: false [e-clin-lo1973] Vitamin E and haemolytic anaemia in premature infants. (1973). https://pubmed.ncbi.nlm.nih.gov/4739911/ DOI: 10.1136/adc.48.5.360
    Complete structured claim and evidence

  2. Peroxide hemolysis normalized within days of oral vitamin E administration and rising blood vitamin E in the premature-infant series.

    Vitamin E → Erythrocyte peroxide-induced hemolysis source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    cross_nutrient
    false
    experimental_model
    Historical clinical series of 50 premature infants aged 6–8 weeks
    exposure
    Blood vitamin E and hydrogen-peroxide hemolysis were assessed; oral vitamin E 10 mg/day was administered.
    limitations
    Historical feeding conditions and infant ages; an ex vivo hemolysis assay is not a universal explanation for anemia of prematurity. Formulation not specified in the abstract.
    nutrient_topic
    Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
    organism
    Homo sapiens
    plain_language
    Restoring vitamin E reduced red-cell fragility in the tested infants.
    primary_references
    [e-clin-lo1973] Vitamin E and haemolytic anaemia in premature infants. (1973). https://pubmed.ncbi.nlm.nih.gov/4739911/ DOI: 10.1136/adc.48.5.360
    tissue_or_cell_type
    Blood and erythrocytes
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 1206–1217

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Historical clinical series of 50 premature infants aged 6–8 weeks · source_derived_draft · unverified_draft

    ### e-clin-infant-peroxide-repletion Peroxide hemolysis normalized within days of oral vitamin E administration and rising blood vitamin E in the premature-infant series. Condition category: nutrient_deficiency nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: Restoring vitamin E reduced red-cell fragility in the tested infants. organism: Homo sapiens tissue_or_cell_type: Blood and erythrocytes experimental_model: Historical clinical series of 50 premature infants aged 6–8 weeks limitations: Historical feeding conditions and infant ages; an ex vivo hemolysis assay is not a universal explanation for anemia of prematurity. Formulation not specified in the abstract. exposure: Blood vitamin E and hydrogen-peroxide hemolysis were assessed; oral vitamin E 10 mg/day was administered. cross_nutrient: false [e-clin-lo1973] Vitamin E and haemolytic anaemia in premature infants. (1973). https://pubmed.ncbi.nlm.nih.gov/4739911/ DOI: 10.1136/adc.48.5.360
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards