{"id":"af5cd6c0-bcc2-596e-82f9-9642d445ebb3","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:e-clin-infant-peroxide-association","predicate":"low_value_associates_with","statement":"In the historical premature-infant series, blood vitamin E below 0.6 mg/100 mL was associated with greater hydrogen-peroxide-induced erythrocyte hemolysis.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"dac084ca-ec08-5dce-a344-34290d548aef","mechanism_event_label":"In this infant study, a low vitamin E reading accompanied fragile red cells in a peroxide test.","subject":{"id":"01f6312f-d08d-5809-bd66-1f002c4195f0","slug":"circulating-alpha-tocopherol","display_name":"Circulating alpha-tocopherol concentration","entity_type_key":"cellular_process"},"object":{"id":"67f93b84-0d39-50d9-ac9b-fdf3b0363afe","slug":"erythrocyte-peroxide-hemolysis","display_name":"Erythrocyte peroxide-induced hemolysis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"dac084ca-ec08-5dce-a344-34290d548aef","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:e-clin-infant-peroxide-association-event","event_type":"observed_intervention","label":"In this infant study, a low vitamin E reading accompanied fragile red cells in a peroxide test.","description":"In the historical premature-infant series, blood vitamin E below 0.6 mg/100 mL was associated with greater hydrogen-peroxide-induced erythrocyte hemolysis.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"da9d64bc-69d4-5d97-90a4-8f0ed03e0ac8","slug":"hydrogen-peroxide","display_name":"Hydrogen peroxide","entity_type_key":"small_molecule"},"role":"ex_vivo_oxidant","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"01f6312f-d08d-5809-bd66-1f002c4195f0","slug":"circulating-alpha-tocopherol","display_name":"Circulating alpha-tocopherol concentration","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"67f93b84-0d39-50d9-ac9b-fdf3b0363afe","slug":"erythrocyte-peroxide-hemolysis","display_name":"Erythrocyte peroxide-induced hemolysis","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Historical clinical series of 50 premature infants aged 6–8 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Blood vitamin E and hydrogen-peroxide hemolysis were assessed; oral vitamin E 10 mg/day was administered.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Historical feeding conditions and infant ages; an ex vivo hemolysis assay is not a universal explanation for anemia of prematurity. Formulation not specified in the abstract. The reported concentration is specific to this study, not a universal cellular adequacy threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin E research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"In this infant study, a low vitamin E reading accompanied fragile red cells in a peroxide test.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[e-clin-lo1973] Vitamin E and haemolytic anaemia in premature infants. (1973). https://pubmed.ncbi.nlm.nih.gov/4739911/ DOI: 10.1136/adc.48.5.360","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Blood and erythrocytes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"2b3fa792-1ecb-5aef-82c2-23145f8d4f8e","evidence_kind":"source_excerpt","locator":"Lines 1193-1204","start_line":1193,"end_line":1204,"excerpt":"### e-clin-infant-peroxide-association\nIn the historical premature-infant series, blood vitamin E below 0.6 mg/100 mL was associated with greater hydrogen-peroxide-induced erythrocyte hemolysis.\nCondition category: biomarker_context\nnutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: In this infant study, a low vitamin E reading accompanied fragile red cells in a peroxide test.\norganism: Homo sapiens\ntissue_or_cell_type: Blood and erythrocytes\nexperimental_model: Historical clinical series of 50 premature infants aged 6–8 weeks\nlimitations: Historical feeding conditions and infant ages; an ex vivo hemolysis assay is not a universal explanation for anemia of prematurity. Formulation not specified in the abstract. The reported concentration is specific to this study, not a universal cellular adequacy threshold.\nexposure: Blood vitamin E and hydrogen-peroxide hemolysis were assessed; oral vitamin E 10 mg/day was administered.\ncross_nutrient: false\n[e-clin-lo1973] Vitamin E and haemolytic anaemia in premature infants. (1973). https://pubmed.ncbi.nlm.nih.gov/4739911/ DOI: 10.1136/adc.48.5.360","model_system":"Historical clinical series of 50 premature infants aged 6–8 weeks","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [e-clin-lo1973] Vitamin E and haemolytic anaemia in premature infants. (1973). https://pubmed.ncbi.nlm.nih.gov/4739911/ DOI: 10.1136/adc.48.5.360","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3ac41dba-4727-5116-a556-ac3bbb0dc41c","stable_key":"import-e0ea2d6a-7429-5e9f-b774-41e5e3288da3","title":"Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a90b6565e092c6a2da07f74cf758792c2cf63b40746260c8ff12bd64322c36f4","revision_id":"956793d1-23e4-5397-9291-25c1732a8e02","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}